Duties: We are seeking a motivated immunologist to study novel pathways that control neutrophil effector functions and their importance in microbial control and inflammatory disease pathogenesis. We will also investigate how these pathways are impacted by neutrophil heterogeneity and the microbiome during microbial infection, intestinal inflammation and cancer. Experience with innate or adaptive immunity, cellular singaling and murine models of infection or immune related disease is essential
Requirements: PhD in immunology, infection biology, biochemistry or cell biology or in the final stages of PhD submission; Good knowledge and experience in immunology and biochemistry; Technical expertise in biochemical, cell biological and mouse work; Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals

Duties: A potential project is to understand the interplay between cell division and cell identity during human development, reprogramming and disease using hESC and organoid models. In this project, some of the specific aims include but are not limited to: To use genome editing technologies to perturb the cell cycle-cell identity cross-talk To measure cell cycle dynamics during cellular transitions by state-of-the-art live cell imaging To integrate sequencing (OMICS) and imaging data sets
Requirements: PhD in areas relevant to Cell, Molecular or Developmental Biology (or in the final stages of PhD submission); Passion for and track record in understanding Gene Regulation and fate decisions; Expertise in sequencing/OMICS approaches (any, including, RNAseq, ATACseq, ChIPseq); Good knowledge of genome editing approaches; Extensive expertise with cell culture

Duties: We have identified a basic mechanism of NET formation that is implicated in anti-fungal defence but also promotes atherosclerosis. We have also uncovered pathways that allow neutrophils to distinguish between different pathogens such as bacteria and fungi and tune NETosis and inflammation for efficient pathogen clearance. We also showed that NETs are highly proinflammatory through their histones and regardless of their origin extracellular histones lead to a break-down of innate and adaptive immunity during sepsis. Ongoing projects in the lab range from areas of basic NET biology and regulation to the regulation of neutrophil heterogeneity and its impact on inflammatory disease through the cross-talk with other immune cells
Requirements: PhD in immunology, infection biology, biochemistry or cell biology or in the final stages of PhD submission; Good knowledge and experience in immunology and biochemistry; Technical expertise in biochemical, cell biological and mouse work

Duties: This project is designed to understand the interactions between tumour cells and immune cells utilising a variety of tumour cell lines and genetic models, with a primary but not exclusive focus on lung cancer and lung metastases. Our laboratory is equipped to track tumour-immune interactions at the single cell level. The LIPSTIC system—Labeling Immune Partnerships by SorTagging Intercellular Contacts—is used to unravel the cellular communication within the tumour microenvironment, concentrating on the interactions between tumour cells and immune cells, as well as between different antigen-presenting cells and T cells
Requirements: PhD in immunology, cancer biology, molecular or cellular biology or in the final stages of PhD submission Good knowledge and experience in immunology and/or tumor biology and/or molecular or cellular biology

Duties: Developing computational methods to model cell fate decisions in hepatocytes which regulate tissue regeneration; Pioneering novel technology platforms for biological validation using bioengineered liver tissue and composite co-culture systems; Combining cell free DNA technologies and machine learning algorithms to detect liver specific somatic mutation and epigenetic signatures during liver regeneration
Requirements: PhD (or in the final stages of PhD submission) in bioinformatics, computational biology, bioengineering, regenerative medicine or related field; Good knowledge and extensive experience in core laboratory skills such as molecular biology, in vitro mammalian cell culture and microscopy including immunohistochemistry

Duties: We are seeking a motivated postdoctoral scientist who will investigate the cellular and molecular mechanisms of organ size evolution using the abdominal epidermis of fruit flies of the Drosophila genus species as model systems
Requirements: PhD in evolutionary developmental biology or a related field, or in the final stages of PhD submission; Strong expertise in evo-devo and comparative evolutionary biology approaches; Interest in working across disciplines with physicists