Postdoctoral Fellow | London, United Kingdom | Francis Crick Institute

Position:	Postdoctoral Fellow
Institution:	Francis Crick Institute
Location:	London, United Kingdom
Duties:	We have identified a basic mechanism of NET formation that is implicated in anti-fungal defence but also promotes atherosclerosis. We have also uncovered pathways that allow neutrophils to distinguish between different pathogens such as bacteria and fungi and tune NETosis and inflammation for efficient pathogen clearance. We also showed that NETs are highly proinflammatory through their histones and regardless of their origin extracellular histones lead to a break-down of innate and adaptive immunity during sepsis. Ongoing projects in the lab range from areas of basic NET biology and regulation to the regulation of neutrophil heterogeneity and its impact on inflammatory disease through the cross-talk with other immune cells
Requirements:	PhD in immunology, infection biology, biochemistry or cell biology or in the final stages of PhD submission; Good knowledge and experience in immunology and biochemistry; Technical expertise in biochemical, cell biological and mouse work

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