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Moderna, Inc.; United States

     Published: February 22, 2024   16:47

     
                        
Duties: Utilize and develop bioinformatics solutions for the analysis of large-scale mass spectrometry experiments (DDA and DIA), focusing on the identification and quantification of MHC-bound peptides (immunopeptidomics); Explore, evaluate, and analyze external (e.g. PRIDE) and internal immunopeptidomics and immunogenomics datasets to support therapeutic target discovery and validation; Interpret complex datasets to drive biologically relevant findings in the context of immunopeptidomics; Collaborate closely with cross-functional research teams to design experiments and refine data acquisition strategies for improved data quality
Requirements: Master's degree +3 years of experience in Biochemistry, Chemistry, Bioinformatics, Computational Biology, or a related field. PhD degree is a plus; Rigorous understanding of mass spectrometry concepts and techniques, including the principles and application of data-dependent acquisition (DDA) and data-independent Acquisition (DIA) methods; Previous hands-on experience with mass spectrometry data analysis software, especially when applied to immunopeptidomics, and the familiarity with the role of MHC molecules in antigen presentation; Experience with RNA-seq and WES data; Strong coding skills in Python and/or R

Scribe Therapeutics; Alameda, California, United States

     Published: February 22, 2024   16:46

     
                        
Duties: Develop novel analysis algorithms and models to better understand and predict CasX editing outcomes and their effects in a therapeutic context; Work closely with Scientists and to inform experimental approaches for testing computational predictions; Effectively communicate analysis approaches and results with close collaborators and across the company; Maintain and improve our existing codebase of bioinformatics pipelines using software development best practices (i.e. version control, workflow management, metadata tracking); Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science
Requirements: PhD in a quantitative discipline (e.g. Computational Biology, Bioinformatics, Biophysics, Systems Biology, Genomics, or equivalent); 2+ years experience developing novel algorithms/analysis methods for integrative analysis of genomics or other biological datasets; 2+ years experience in computational and statistical programming (python or R preferred), unix command line, bioinformatic toolkits, version control systems (e.g. git), and workflow management (e.g. nextflow)

Centre national de la recherche scientifique (CNRS); France

     Deadline: March 5, 2024 | Published: February 22, 2024   16:45

     
                        
Duties: Mettre en place des cultures bactériennes anaérobies; Mettre en œuvre des techniques de biologie moléculaire et de génétique bactérienne pour cloner les gènes des hydrogénases recombinantes et pour construire les souches bactériennes d’expression; Mettre en œuvre des techniques de biochimie pour purifier des hydrogénases recombinantes; Mettre en œuvre des techniques de biochimie pour la caractérisation biochimique des enzymes purifiées; Analyser et interpréter les résultats obtenus; Présenter les résultats expérimentaux lors de réunions et séminaires
Requirements: Compétences en biologie moléculaire (PCR, digestion enzymatique, …); Compétences en biochimie (purification de protéines, mesure d'activité enzymatique, SDS-PAGE, Western Blot…); Cultures bactériennes; Le candidat/la candidate sera idéalement familier(e) avec les cultures bactériennes anaérobies et avec la manipulation de metalloenzymes; Respect des règles d’hygiène et sécurité

University of New South Wales (UNSW); Kensington, New South Wales, Australia

     Deadline: March 10, 2024 | Published: February 22, 2024   16:44

     
                        
Duties: We are looking for Lecturers or Senior Lecturers that will make a significant contribution to the delivery of the Bachelor of Exercise Science/Masters of Physiotherapy and Exercise Physiology program. The roles will focus on teaching within the discipline of Physiotherapy in the School of Health Sciences, and we are specifically seeking academics with expertise within the sub-disciplinary area of neurological physiotherapy, musculoskeletal physiotherapy and/or physiotherapy across the lifespan. Research track records in these disciplines will also be considered favourably
Requirements: A PhD in Physiotherapy or other related health/medical disciplines and registration with AHPRA as a physiotherapist in Australia; Clinical expertise in an area of physiotherapy complementary to the School of Health Sciences team (this may include neurological, musculoskeletal or physiotherapy across the lifespan e.g., paediatric, women’s health and aged care)

University of Oxford; Oxford, Oxfordshire, United Kingdom

     Deadline: March 6, 2024 | Published: February 22, 2024   16:43

     
                        
Duties: You will be primarily responsible for the development of methods to obtain comparable measures from scans acquired with different hardware in both clinical and research settings. This will involve i) assessing variability of brain-health markers across hardware and its impact on clinically-relevant outcomes; ii) developing a strategy to minimise non-biological variability in the measures and iii) implement it at the acquisition and/or image processing level. The project is in close collaboration with the University of Manchester, which will also provide access to brain scanners from three major vendors in clinics across the city with the aim of creating a standard output from all clinical settings. Some of your duties include developing questions, generate original ideas, and conduct individual research on data harmonisation approaches and techniques to standardise imaging phenotypes across MRI scanner platforms, contribute to the development of the harmonisation strategy for BRC and p...
Requirements: It is essential that you hold a PhD/DPhil in engineering, physics, neuroimaging, or other related subject, have expertise in MRI analysis, ideally using FSL and expertise in scientific computation, optimisation techniques, and/or statistical methods. It is desirable that you have experience with neuroimaging and/or a background in neuroscience, experience with machine learning and/or advance regression methods and a track record of independence, such as managing a research project and/or supervision

National Taiwan University (NTU); Taipei City, Taipei, Taiwan

     Deadline: May 31, 2024 | Published: February 22, 2024   16:36

     
                        
Duties: Upon hiring, the successful candidate is expected to develop and lead an individual research program and to share our commitment to undergraduate and graduate education by teaching courses and supervising graduate and undergraduate research
Requirements: We are interested in candidates who have a Ph.D. or equivalent with postdoctoral research experience pursuing innovative approaches to fundamental problems in Plant Nematodes and Nematode Biology

Swedish University of Agricultural Sciences (SLU); Uppsala, Uppsala County, Sweden

     Deadline: March 21, 2024 | Published: February 22, 2024   16:34

     
                        
Duties: An increased use of beef bull semen in dairy herds is a climate-efficient way to increase meat production and profitability for producers. The ease with which calves are born and their production traits are affected by sex, breed combination and their parents' breeding values. The production systems differ between countries and knowledge is needed about optimal strategies for using beef semen under Swedish conditions. The project aims to, through interviews and data analyses, map different production systems and the need for beef x dairy crossbred calves of different sexes and genetic level. Economic calculations are planned to investigate how the breeding index for beef bulls should be supplemented to suit different production systems for beef x dairy crosses. How well the ranking of bulls corresponds with their offsprings' performance will be studied. The project will be run in close collaboration with the industry and exchange knowledge with a similar Danish project. The doctoral pr...
Requirements: You have an education in animal science/veterinary medicine/biology/agricultural economics or similar. At the start of the doctoral studies, you must have a master's degree (or equivalent), or at least four years of full-time studies, of which at least one year is at advanced level, and you have a strong interest in breeding, statistics, production systems and economics. It is advantageous to have experience in handling large amounts of data and to have knowledge of Swedish dairy and beef production. You must be able to communicate freely in spoken and written English. The ability to understand and speak Swedish or another Scandinavian language is meritorious. Due to the close cooperation with industry in the project, we will also emphasize good social skills. Ability to work both in a team and independently and initiative are also meritorious for the position

F. Hoffmann-La Roche AG; Shanghai, China

     Published: February 22, 2024   16:07

     
                        
Duties: Partner with AI researchers and bioinformaticians to develop novel computational methods to infer causality in disease progression; Work closely with biologists in Immunology and Oncology to solve biological questions and validate computational findings; Contribute to drug projects by providing support on target identification and validation, biomarker discovery, patient stratification, clinical trial design, etc; Analyze multi-omics and phenotyping data from research studies, clinical trials and real world databases to identify disease-driving cell types, pathways, and genes
Requirements: Ph.D. degree in bioinformatics, biology, computational biology or a relevant field. Experience in the pharmaceutical industry is preferred; 5+ years of industry experience, or 3+ years in industry plus 2+ years academic post-doc experience; Passion for in-depth understanding of biological questions and finding plausible answers with data analytics; Solid biology knowledge in Immunology or Oncology, being able to communicate comfortably with biologists

Moderna, Inc.; Oxford, United Kingdom

     Published: February 22, 2024   16:05

     
                        
Duties: This pivotal role involves monitoring and maintaining bioinformatics pipelines, ensuring compliance with standards, and aiding in the development or specification of methods and procedures for product quality assurance. You will collaborate with bioinformatics and software engineers to design and develop automated tools, playing a crucial part in ensuring the continuous operation of our bioinformatics pipelines
Requirements: Bachelor's degree in Computer Science, Engineering, or a related field with 10+ years of relevant experience, or a Master’s degree with a minimum of 5 years’ experience; Strong programming skills in Python and Linux; Experience with bioinformatics workflow frameworks (NextFlow preferred), version control systems (Git preferred), Cloud (AWS preferred), and containers (Docker preferred); Experience in a regulated environment with knowledge of compliance requirements

The Wistar Institute; United States

     Published: February 22, 2024   16:04

     
                        
Duties: Apply and develop bioinformatics approaches for analysis of data from high-throughput experiments conducted by Wistar Institute scientists, including but not limited to bulk and single cell next generation sequencing and other various types of genomics and proteomics data; Design, implement, and evaluate new bioinformatics programs to extend the services and capabilities of the facility; Develop and implement application for management, analysis and representation of different types of data, including interface implementations of scientific algorithms and to write comprehensive reports; Execute special projects as assigned and attend project meetings as appropriate
Requirements: Master’s degree in Bioinformatics/Mathematical/Physical/Computational Sciences or related fields required, PhD preferred. Minimum of one-year prior experience in Bioinformatics data analysis and scientific software development for high throughput data (next generation sequencing, proteomics, other platforms) is preferred. Experience in programming languages (e.g. Python or Perl) and experience in R or Matlab statistical environments is required. The ideal candidate will have experience with analysis of most next generation sequencing approaches, including bulk and single cell RNA-seq, CHIP/CUT&RUN/ATAC-seq, HiCHIP/HiC data analyses. Relational database development and website integration knowledge is a plus

University of Oxford; Oxford, Oxfordshire, United Kingdom

     Deadline: March 15, 2024 | Published: February 22, 2024   16:03

     
                        
Duties: As a Clinical Research Fellow, you will be responsible for providing clinical input into the design and execution of clinical trials with other team members and lead on the clinical delivery of these trials. You will work closely with the clinical trials team including project managers, nurses, recruitment coordinators and data managers. According to clinical trial protocols, you will conduct screening of volunteers and provide medical oversight for administration of vaccines and infectious agents for human challenge studies. Additionally, you will undertake administrative work supporting clinical trial conduct including regulatory oversight and safety reporting
Requirements: It is essential that you are a GMC registered medical doctor and educated to degree level or equivalent in a relevant subject. You must be currently qualified and license to practise medicine in the UK. You will have relevant experience in clinical medicine, equivalent to completion of core medical training as a minimum. You will have excellent verbal and written communication skills together with an ability to work independently and as a team member. Having experience working in clinical studies is desirable

Centre national de la recherche scientifique (CNRS); France

     Deadline: March 6, 2024 | Published: February 22, 2024   16:00

     
                        
Duties: Réaliser l’optimisation et la mise en oeuvre des instruments analytiques mis à disposition; Contribuer au développement d’une méthode d’analyse de MP/NP présents dans des matrices biologiques; Synthétiser des particules de nanoplastiques étalons par différentes méthodes (TOP-DOWN et BOTTOM-UP); Contribuer au développement d’une méthode d’analyse afin de caractériser en concentration et en taille les particules synthétisées; Extraire les résultats bruts, les mettre en forme et les présenter au sein du groupe projet; Gérer l’approvisionnement en matériel et en produits notamment en prévoyant les besoins
Requirements: Connaître de façon théorique et pratique la synthèse de nano plastiques; Connaître de façon théorique et pratique les techniques d’analyses en taille et en concentration de nanoparticules; Savoir rédiger un rapport scientifique; Avoir la capacité de s’intégrer rapidement au sein d’une équipe; Savoir travailler en équipe

Francis Crick Institute; London, United Kingdom

     Deadline: March 19, 2024 | Published: February 22, 2024   15:56

     
                        
Duties: Signal Transduction allows cells to respond to extracellular cues. Which and how strongly distinct signalling pathways are activated in individual cells varies from cell to cell and depends on their molecular makeup. The impact of the molecular makeup's effect on signalling can be examined through two perspectives: top-down and bottom-up. From the top-down view, molecular makeup is summarized as cell states that indirectly affects signal transduction. Conversely, the bottom-up approach focuses on how the levels of specific proteins directly modifies signal transmission
Requirements: Candidates from diverse backgrounds, including but not limited to Systems Biology, Natural Sciences, Bioinformatics, Computer Science, Data Science, Mathematics and Physics, are encouraged to apply. A quantitative mindset, coding experience (Python/Julia/C or similar language) and an interest in solving biological problems is expected

Tampere University; Tampere, Pirkanmaa, Finland

     Deadline: March 18, 2024 | Published: February 22, 2024   15:52

     
                        
Duties: Developing high-throughput molecular assays to monitor epigenetic changes upon chemical and drug exposure; Designing and optimising high-throughput PCR and sequencing-based assays from in vitro experiments; Developing high-throughput experimental pipelines by using advanced pipetting robot facilities
Requirements: The ideal candidate holds a PhD degree in an applicable field of molecular biology or related subject area and has demonstrated (through published articles) the required competence. A strong background in molecular biology and epigenomics Knowledge of qPCR and DNA sequencing data analysis and modelling Knowledge of dose-dependent analysis Knowledge of cell biology techniques Knowledge of in vitro (human models) toxicology and pharmacology

University of Oxford; Oxford, Oxfordshire, United Kingdom

     Deadline: March 4, 2024 | Published: February 22, 2024   15:43

     
                        
Duties: We are looking for an enthusiastic postdoctoral researcher looking to develop an independent research career is required for a cutting-edge program of research to systematically investigate calcium channel antagonists as a class of drugs with potential for disease modification in amyotrophic lateral sclerosis (ALS). Several members of the class of CCBs will be assessed for phenotypical modification and target engagement across a range of cellular models (an ESC-derived motor neuron model of ALS, iPSC-models based on a number of ALS determining mutations). Specifically, we aim to 1) Establish whether the effect of CCBs (for which we have preliminary evidence) is a class effect, 2) determine the specific targets of calcium channel blockers, which mediate improved survival in our cellular models, 3) in collaboration with colleagues in Edinburgh extend testing to mouse and zebrafish models
Requirements: It is essential that you hold or be close to award of a doctorate (PhD/DPhil) in Neuroscience, have a proven track record in cell culture (particularly iPSC and ESC-derived neuronal cell culture) and experience in molecular biology techniques

Imperial College London (ICL); London, United Kingdom

     Deadline: March 17, 2024 | Published: February 22, 2024   15:36

     
                        
Duties: Based at Imperial College’s South Kensington campus, you will work within Dr Child’s team and will: Operate as experimental team lead and bridge the gap between experimental technology development and clinical variant interpretation; Collaborate closely with researchers from the wider cluster to ensure seamless integration of tools, workflows, and data outputs; Contribute to the development of cross-platform translation strategies to enhance the efficiency of functional genomic pipelines; Lead the primary experimental high throughput analysis of missense variant function
Requirements: Hold, or be near completion of, a Ph.D. in Functional Genomics, Chemoprotogenomics or a related discipline, or equivalent research, industrial or commercial experience; Broad expertise in both experimental technology development and variant interpretation; Proven experience in interdisciplinary research projects; Basic programming skills and experience with high-throughput proteomic analyses are advantageous; Excellent written and verbal communication skills; Ability to work collaboratively in a multidisciplinary research environment; Track record of scientific publications in peer-reviewed journals; Proven ability to independently drive research projects; Retain strong focus on interoperability throughout to ensure data outputs readily translate between the learning, prediction and analysis platforms that contribute to the broader cluster

University of Leeds; Leeds, West Yorkshire, United Kingdom

     Deadline: March 5, 2024 | Published: February 22, 2024   15:34

     
                        
Duties: We have an exciting opportunity for a Research Technician in Molecular Virology to join our multidisciplinary team studying arbovirus biology. Funded as part of a Medical Research Council award to Dr Tuplin, the project focusses on understanding how chikungunya virus regulates translation and replication of its genome in human and mosquito host cells. The project will use a range of molecular cell biology, RNAseq, infectious clone and structural approaches to increase our understanding of virus biology, with the ultimate goal of identifying novel targets for antiviral intervention
Requirements: You should have a Degree, BTEC higher level or equivalent or equivalent experience, with experience in molecular and cellular biology (e.g. PCR, qRT-PCR, cloning, purification of DNA, SDS PAGE, western blotting), ideally with experience of working with viruses

Amgen Inc.; Burnaby, Canada

     Published: February 22, 2024   15:30

     
                        
Duties: Serve as the bioinformatics lead on a collaborative project focused on characterizing induced immune responses in an in vitro immunogenicity model; Perform analysis of scRNAseq and proteomics data; Perform rational multi omic integration of resulting data; Use the relevant data to generate training sets for Machine Learning; Play a key role in data collection, model training, and deployment for property prediction; The postdoctoral fellow will also receive personalized training in relevant areas of Machine Learning or immunology, as needed
Requirements: Doctorate degree in bioinformatics or a related field; Understanding of basic concepts of immunology; Significant experience in single-cell RNAseq analysis pipelines; Excellent communicator able to write and speak about technical concepts to business, technical, and lay audiences

University of New South Wales (UNSW); Kensington, New South Wales, Australia

     Deadline: March 10, 2024 | Published: February 22, 2024   15:12

     
                        
Duties: We are looking for Lecturers or Senior Lecturers that will make a significant contribution to the delivery of the Bachelor of Exercise Science/Masters of Physiotherapy and Exercise Physiology program. The roles will focus on teaching within the discipline of Physiotherapy in the School of Health Sciences, and we are specifically seeking academics with expertise within the sub-disciplinary area of neurological physiotherapy, musculoskeletal physiotherapy and/or physiotherapy across the lifespan. Research track records in these disciplines will also be considered favourably
Requirements: A PhD in Physiotherapy or other related health/medical disciplines and registration with AHPRA as a physiotherapist in Australia; Clinical expertise in an area of physiotherapy complementary to the School of Health Sciences team (this may include neurological, musculoskeletal or physiotherapy across the lifespan e.g., paediatric, women’s health and aged care)

Ginkgo Bioworks; United States

     Published: February 22, 2024   15:09

     
                        
Duties: Support biosurveillance programs by providing technical expertise on program design (including pathogen selection, location, sample size, and testing frequency), as well as data interpretation, contextualization, and ongoing evaluation of data to ensure data quality standards are met; Serve as an integral member of the team providing data and insights to clients on a daily cadence; Work with the Bioinformatics and Epi and Modeling teams to integrate program and contextual data into one “story” for customers and partners; Play a key role in shaping the biosurveillance product by providing insights and recommendations based on your expertise in epidemiology and biosurveillance; Provide general analytic and epidemiological support to different parts of the organization; Interface with internal and external customers as a subject matter expert; Act as a key technical liaison during sales calls and proposal development, providing in-depth knowledge of biosurveillance methodologies and t...
Requirements: PhD (strongly preferred) with a minimum of 8 years of relevant experience, OR Master’s with 10 years of relevant experience; Strong understanding of epidemiology, infectious disease models, and statistical principles; Experience with study design and working with biosurveillance data; Experience working in domestic and international contexts; Experience using a variety of statistical and machine-learning methods; Experience developing models from the ground up; Experience working with diverse data (big, small, sparse, empirical, modeled, etc.)

AbbVie Inc.; South San Francisco, California, United States

     Published: February 22, 2024   15:05

     
                        
Duties: Lead Oncology Bioinformatics efforts to enable critical data input and impact decision-making of advancing AbbVie’s antibody-drug conjugate platform; A key contributor in establishing and executing computational strategy leveraging proprietary multi-modal, pre-clinical and human derived cancer omics data assets for target and biomarker discovery; Support and/or expand Companion Diagnostics (CDx) development to enable precision oncology strategy for ADC programs; Responsible for formulating scientific questions into coherent analytical efforts, developing rigorous statistical and machine learning methods, and communicating scientific findings to internal and external stakeholders; Design novel omics profiling on pre-clinical models and patient tumor samples, and generate insights for ADC target identification and validation through omics-analysis
Requirements: PhD, or MS in bioinformatics, statistics, mathematics, computer science, computational biology, genomics or a related field with typically 0+ (PhD), 5+ (MS) years of working experience; Proficient in at least one general purpose programming/data science languages including but not limited to R, Python, Julia; Experience with common NGS data processing tools, statistical analysis, and machine learning; Understanding of cancer genetics and experience in analyzing multi-modal patient derived tumor genomics data; Understanding of cancer biology

London School of Hygiene & Tropical Medicine (LSHTM); London, United Kingdom

     Deadline: March 4, 2024 | Published: February 22, 2024   15:04

     
                        
Duties: The successful applicant will carry out laboratory research on microbiology and cell biology and prepare manuscripts for submission to scientific journals. The work will involve biochemical, molecular, genetic and cell biological approaches and would suit an individual with a background in molecular cell biology
Requirements: The successful applicant will have a postgraduate degree, ideally a doctoral degree, in a relevant topic, relevant experience in microscopy, practical experience in a broad range of techniques that apply to microscopy including image acquisition, image analysis, computer programming, ImageJ, deconvolution softwares. Further particulars are available in the job description

Università degli Studi di Firenze; Firenze, Italy

     Deadline: March 11, 2024 | Published: February 22, 2024   15:03

     
                        
Department: Medical Sciences; Medicine
Duration: 1 y
Duties: STAT3-related inborn errors of immunity: unraveling disease mechanisms and potential targets
Requirements: Experienced researcher or 4-10 yrs (Post-Doc)

Moffitt Cancer Center; Tampa, Florida, United States

     Published: February 22, 2024   15:02

     
                        
Duties: Provide strong leadership, mentorship of a large and diverse department of faculty and staff; Provide scientific direction/oversight of the Biostatistics and Bioinformatics Shared Resource; Build relationships with faculty and staff both in the Biostatistics and Bioinformatics Department and across the Moffitt Cancer Center to promote a collaborative environment
Requirements: Successful candidates must have a Ph.D. in statistics, biostatistics or related field and relevant research training and experience (currently Associate- or Full Professor-equivalent rank); Preference will be given to applicants with an outstanding record doing team science or collaborative data science, specifically in cancer

Francis Crick Institute; London, United Kingdom

     Deadline: March 5, 2024 | Published: February 22, 2024   14:49

     
                        
Duties: Mouse Primordial Germ Cells (PGCs) and their in vitro counterparts, PGC-like cells (PGCLCs), are the precursors to gametes and are a critical part of the intergenerational life cycle, specified during early embryogenesis. While PGCLCs are traditionally generated in the lab through application of specific signalling cocktails to bias cell decisions towards a germ cell state, it is becoming apparent that these techniques might not fully capture the complex feedback systems in place in the embryo that are used to specify, migrate and mature PGCs in vivo. Instead, we have used 3D mouse gastruloids as a model of early embryogenesis and see that such structures reproducibly generate PGCLCs
Requirements: PhD in Biology/Genetics/Development or similar, or in the final stages of PhD submission; Solid background, knowledge of and experience with PGCs or germ cells; Technical expertise in stem cell culture, particularly mouse or human embryonic stem cells; Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals


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