Conduct research as a Master's student in the Knoblich lab to investigate how healthy network activity is established in human brain development and to identify the mechanisms by which genetic perturbations affect this process
Requirements:
Highly motivated with a strong interest in brain development and neuroscience; Experience in molecular biology and cell culture (essential); Bioinformatics experience or programming skills in Python and R (an advantage); Openness to diversity and all qualified individuals regardless of background are encouraged to apply
Text:
:"# Masteru2019s project in human neuronal network development | Knoblich labnnDecember 18, 2025nnJoin the Knoblich lab as a Master's student and investigate how healthy network activity is established in human brain development and to identify the mechanisms by which genetic perturbations derail this process.nnnn---nn## About the Knoblich LabnnThe Knoblich lab studies the development of the human brain and the mechanisms of neurodevelopmental disorders. To study these mechanisms, the Knoblich lab developed cerebral organoids - 3D stem-cell-derived models that recapitulate the earliest steps of human brain formation, including the development of neuronal network activity. Human brain networks arise through the coordinated maturation of diverse neuronal subtypes, the establishment of synaptic connections, and the gradual refinement of excitatory-inhibitory balance. These processes shape how neurons communicate, organize into circuits, and generate complex patterns of activity that underlie behavior. Remarkably, as cerebral organoids mature, they form functional neuronal circuits, offering a unique opportunity to connect cellular development with emerging network activity in a human context.nn## Research areannUsing state-of-the-art genetic and electrophysiological tools, this project aims to understand how healthy network activity is established in human brain development and to identify the mechanisms by which genetic perturbations derail this process. In this project, the techniques that the applicant will be exposed to include:nn- Human stem cell and organoid culturen- AAV productionn- Rabies-virus-based monosynaptic tracingn- Advanced intra- and extracellular electrophysiological techniquesn- Bioinformatics analysisn- Immunohistochemistryn- Confocal and 2-Photon microscopynn## Your profilennApplicants should be highly motivated and have an outstanding interest in brain development and neuroscience.nnExperience in molecular biology and cell culture is essential. Bioinformatics experience (or general programming skills in Python and R) is an advantage.nnWe value diversity and strongly encourage applications from all qualified individuals, regardless of background, race, gender, or personal identity.nn## Affiliated institutionsnn- n- nn## Our offernnThis is an offer for an exciting project at one of the leading institutes in life sciences in Europe with unparalleled scientific infrastructure and a great work environment. The masteru2019s project is planned for 12 months (ideally master thesis). The position includes a monthly stipend of ~ u20ac 1,062, corresponding to a total gross annual salary of u20ac 15,000. Your application should include CV, letter of motivation and contact details of your referees.nn[Apply now.](https://imba.onlyfy.jobs/application/de/apply/uumhm3flp84atfnuejpflbcbzxrfqa8)nn## ContactnnInstitute of Molecular BiotechnologynnDr. Bohr-Gasse 3nn1030 Vienna, Austriann[ 43-1-790 44](tel: 43179044)nn[office(at)imba.oeaw.ac.at](mailto:office@imba.oeaw.ac.at)nn## Vienna BioCenternn[](http://viennabiocenter.org/)",
Please click here, if the job didn't load correctly.
Please wait. You are being redirected to the job in 1 seconds.
