Within this project the possibilities to control the production phase of recombinantly produced proteins will be explored. Special attention will be placed on the control of cell physiological parameters during the production phase. Physiological parameter include biomass specific rates such as nutrient uptake, oxygen consumption, carbon dioxide production as well as inducer consumption and product formation rates. To control them predetermined dynamic feed profiles and advanced and predictive control structures will be applied on multiple feeds. This does not only lead to increased productivities and better scalable processes but also to a stabilization of the production phase, which is an important step towards continuous biomanufacturing
Requirements:
You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree (e.g.: a MSc degree equivalent to at least 5 years of studies including a BSc degree) in (bio)chemical engineering, process engineering, bioengineering, biotechnology, biochemistry, molecular Biology or similar
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PhD scholarship in Physiological Bioprocess Control Within this project the possibilities to control the production phase of recombinantly produced proteins will be explored. Special attention will be placed on the control of cell physiological parameters during the production phase. Physiological parameter include biomass specific rates such as nutrient uptake, oxygen consumption, carbon dioxide production as well as inducer consumption and product formation rates. To control them predetermined dynamic feed profiles and advanced and predictive control structures will be applied on multiple feeds. This does not only lead to increased productivities and better scalable processes but also to a stabilization of the production phase, which is an important step towards continuous biomanufacturing You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree (e.g.: a MSc degree equivalent to at least 5 years of studies including a BSc degree) in (bio)chemical engineering, process engineering, bioengineering, biotechnology, biochemistry, molecular Biology or similar
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