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Position: Postdoc position, wet lab and/or computational
Institution: Institut für Molekulare Biotechnologie GmbH
Location: Wien, Austria
Duties: In recent years, the 3D genome organization has arisen as a critical regulator for gene regulation and an important factor in shaping cell type specification. However, the mechanisms by which spatial organization of DNA, RNA, and proteins impact nuclear functions post fertilization remains still unclear. In Jachowicz lab we aim to understand the interplay between 3D genome organization and the transcriptome across early mammalian development. We focus on investigating the regulatory role of “dark” genome elements in shaping nuclear functions during early development and use embryonic stem cells and early mouse embryos as model systems. To address our questions, we employ novel, genome-wide technologies based on Split-Pool Recognition of Interactions by Tag Extension (SPRITE) that allow us to simultaneously measure 3D nuclear organization and the transcriptome
Requirements: The candidate should hold a PhD (or be close to completion) in genomics, molecular biology, developmental biology, or computational biology
   
Text: Postdoc position, wet lab and/or computational In recent years, the 3D genome organization has arisen as a critical regulator for gene regulation and an important factor in shaping cell type specification. However, the mechanisms by which spatial organization of DNA, RNA, and proteins impact nuclear functions post fertilization remains still unclear. In Jachowicz lab we aim to understand the interplay between 3D genome organization and the transcriptome across early mammalian development. We focus on investigating the regulatory role of “dark” genome elements in shaping nuclear functions during early development and use embryonic stem cells and early mouse embryos as model systems. To address our questions, we employ novel, genome-wide technologies based on Split-Pool Recognition of Interactions by Tag Extension (SPRITE) that allow us to simultaneously measure 3D nuclear organization and the transcriptome The candidate should hold a PhD (or be close to completion) in genomics, molecular biology, developmental biology, or computational biology
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