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Position: Research Fellow/Senior Research Fellow
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: This is an outstanding opportunity for either a Research Fellow or Senior Research Fellow to work independently on a newly funded project from a grant from the GOSH Sparks Charity. Our objectives are: 1) To improve the diagnostic yield of WES/WGS for children with suspected neurometabolic disorders, 2) To generate robust analytic pipelines for transcriptomic data that can be integrated into clinical care pathways in this context and potentially more broadly, and 3) To explore the use of transcriptomic data to improve our understanding of the pathogenesis of neurometabolic diseases with a view to identifying novel therapeutic targets
Requirements: The candidate will have PhD Degree in Neuroscience, Biostatistics, Mathematics, Physics or related discipline, experience with computational biology and sequence data analysis (DNA or RNA)/Proficient with computational biology and sequence data analysis (DNA or RNA) and experience using programming languages: R/Proficient using programming languages: R. Knowledge and experience of bulk tissue RNA-sequencing data analysis, knowledge and experience of long read RNA-sequencing data generation and analysis and proficient in a RNA extraction, cDNA generation, primer design, RT-PCR and Sanger sequencing are desirable but essential for grade 8 Sr Research Fellow position
   
Text: Research Fellow/ Senior Research Fellow, - Ref:1886508 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grades 7-8 Hours Full Time Salary (inclusive of London allowance) G7-£36,770 £44,388 per annum. G8- £45,610 - £48,167 per annum Duties and Responsibilities This is an outstanding opportunity for either a Research Fellow or Senior Research Fellow to work independently on a newly funded project from a grant from the GOSH Sparks Charity. Our objectives are: 1) To improve the diagnostic yield of WES/WGS for children with suspected neurometabolic disorders, 2) To generate robust analytic pipelines for transcriptomic data that can be integrated into clinical care pathways in this context and potentially more broadly, and 3) To explore the use of transcriptomic data to improve our understanding of the pathogenesis of neurometabolic diseases with a view to identifying novel therapeutic targets. By completing these three objectives we aim to both transform diagnostics for inherited neurometabolic disorders, and help kickstart the next wave of therapeutic research in this field. The post holder will quality control of short and long read RNA-sequencing data, application of analytic pipelines for short and long read RNA sequencing data and design and completion of experiments for isolation and/or amplification of specific RNA transcripts. This post is funded until 30 June 2024 in the first instance. Key Requirements The candidate will have PhD Degree in Neuroscience, Biostatistics, Mathematics, Physics or related discipline, experience with computational biology and sequence data analysis (DNA or RNA)/ Proficient with computational biology and sequence data analysis (DNA or RNA) and experience using programming languages: R/ Proficient using programming languages: R. Knowledge and experience of bulk tissue RNA-sequencing data analysis, knowledge and experience of long read RNA-sequencing data generation and analysis and proficient in a RNA extraction, cDNA generation, primer design, RT-PCR and Sanger sequencing are desirable but essential for grade 8 Sr Research Fellow position. Further Details At GOS ICH we aim to always have a balanced interview panel that is representative of gender and ethnic diversity. A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference We particularly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level. UCL Taking Action for Equality Closing Date 23 Nov 2022 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Gold award, in recognition of our long-term commitment and 'beacon' status in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and PS Apply Now
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