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Position: Postdoctoral Researcher for Preclinical Studies on Peroxisomal Biogenesis Disorders
Institution: University of Luxembourg
Location: Luxembourg City, Luxembourg
Duties: Testing small molecule compounds and performing functional assays in human cultured cells (e.g. Western Blot and enzymatic assays); Applying various imaging techniques in cultured cells; Performance of experiments using zebrafish embryos/larvae, e.g. microinjections, behavioral tests, open field recordings, immunohistochemistry, in vivo microscopy; Application of genome-editing techniques in zebrafish: transient knockdown using morpholinos, genome editing using CRISPR/Cas9, gene overexpression by Tol2 transposon system; Organ dissection, cryodissection of tissues for imaging purposes; Performing molecular biology experiments, such as PCR-based genotyping, cloning, and gene expression analysis by qPCR
Requirements: PhD degree in molecular biology, cell biology, biochemistry, genetics, or another similar life science-related discipline; Mobile and enthusiastic about the bilateral (Luxembourg-McGill) collaboration scheme, which involves working in both locations; Strong drive for experimental work, including the handling of model organisms, and a high curiosity to decipherdisease mechanisms; Strong theoretical background and practical experience in metabolicbiochemistry, molecular and cell biology, and genetics
   
Text: UOL05223 31-Dec-2099 The University | About us... The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres ;focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide. At the Luxembourg Centre for Systems Biomedicine (LCSB) the Enzymology & Metabolism Research Group headed by Dr. Carole Linster focuses on 1) enzyme function discovery and elucidating the (patho)physiological functions of more recently identified metabolic enzymes; and 2) on generating disease models for selected inborn errors of metabolism to study underlying disease mechanisms and/or investigate treatment options. The group develops advanced phenotyping techniques, including metabolomics, to address related research questions and uses budding yeast, zebrafish, and mammalian cell culture, including iPSC-derived cells, as main model systems. We are looking for a highly skilled and scientifically driven researcher to work on a project that will use in vitro and in vivo models for finding new therapeutic approaches for Zellweger Spectrum Disorders. The project will be carried out as a collaboration between the Linster lab and the group of Dr. Nancy Braverman (McGill University), a leader in the study of peroxisome biology and related disorders for more than 15 years. It will include the validation of previously identified hit compounds in cellular models and deep phenotyping of existing zebrafish disease models to study the mechanisms underlying the disease. The project will also involve traveling to Montreal as part of the work will be implemented in the Braverman lab. Your Role... More specifically the tasks include: Testing small molecule compounds and performing functional assays in human cultured cells ( e.g. Western Blot and enzymatic assays) Applying various imaging techniques in cultured cells Performance of experiments using zebrafish embryos/larvae, e.g. microinjections, behavioral tests, open field recordings, immunohistochemistry, in vivo microscopy Application of genome-editing techniques in zebrafish: transient knockdown using morpholinos, genome editing using CRISPR/Cas9, gene overexpression by Tol2 transposon system Organ dissection, cryodissection of tissues for imaging purposes Performing molecular biology experiments, such as PCR-based genotyping, cloning, and gene expression analysis by qPCR Contribution to transcriptomics and metabolomics experiments, such as metabolite/RNA extractions, LC-MS metabolite analyses, RNA-seq Development of phenotypic drug screens in zebrafish larvae Modern data management and precise project documentation Working in a collaborative environment, also with different service-based core platforms (animal, sequencing, metabolomics, and imaging facilities) Active participation in group meetings Independent drafting of project reports and potentially grant proposals Writing manuscripts for publication in high quality journals as well as presenting research findings at international scientific meetings What we expect from you… PhD degree in molecular biology, cell biology, biochemistry, genetics, or another similar life science-related discipline Mobile and enthusiastic about the bilateral (Luxembourg-McGill) collaboration scheme, which involves working in both locations Strong drive for experimental work, including the handling of model organisms, and a high curiosity to decipher disease mechanisms Strong theoretical background and practical experience in metabolic biochemistry, molecular and cell biology, and genetics Experience with molecular biology and microscopy techniques is essential Previous experience with zebrafish models and mammalian cell culture will be considered as important assets (animal laboratory science certificate Function A or B according to the European Directive 2010/63/EU, or equivalent, is required) Good knowledge of peroxisomal biology will be considered as an advantage Previous work in the field of metabolic biochemistry will be considered as an advantage Solid bioinformatic and biostatistics skills will be required Excellent organizational and management skills Excellent communication skills Fluency in oral and written English is essential In Short... Contract Type: Fixed Term Contract 24 Month Foreseen starting date: December 2022 Work Hours: Full Time 40.0 Hours per Week Location: Belval Job Reference: UOL05223 The yearly gross salary for every Postdoctoral Researcher at the UL is EUR 77167 (full time) How to apply... Applications (in English) should contain the following documents: A detailed Curriculum vitae including a list of publications A cover letter that includes a brief description of previous research experience and the motivation for the specific advertised position Copies of diploma and transcripts A scan of your animal laboratory science certificate (Function A or B required) Name and contact details of at least three referees Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered. The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. In return you will get… Multilingual and international character . Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR). A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure. A partner for society and industry . Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs … Find out more about the University Addresses, maps & routes to the various sites of the University Further information... Questions can be addressed to: carole.linster@uni.lu
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