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Position: Research Fellow in Structural Biology
Institution: University of Leeds
Department: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology
Location: Leeds, West Yorkshire, United Kingdom
Duties: We are looking for an outstanding postdoctoral research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, the link between disease-relevant mutations and post-translational modifications and fibril structure, and how these aggregates perturb cells. This Wellcome-funded role is to use cryoEM, supported with other biophysical analyses, to understand amyloid fibril structure, especially of fibrils purified from patient samples. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid aggregate formation and the consequences of aggregation on cellular function
Requirements: You should have a PhD (or be close to completing one) in Structural Biology, Biochemistry, or a related discipline, and you should have extensive experience of using structural methods to elucidate biological mechanisms. Experience in cryo-electron microscopy/tomography would be a significant advantage, but training will be given to outstanding structural biologists lacking this experience but able to evidence their passion and commitment to learn cryo-EM techniques
   
Text: Research Fellow in Structural Biology Are you looking to apply your skills in Structural Biology and Imaging to gain a new molecular understanding of the structure of amyloid aggregates and help to develop new routes to combat amyloid diseases? We are looking for an outstanding postdoctoral research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, the link between disease-relevant mutations and post-translational modifications and fibril structure, and how these aggregates perturb cells. This Wellcome-funded role is to use cryoEM, supported with other biophysical analyses, to understand amyloid fibril structure, especially of fibrils purified from patient samples. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid aggregate formation and the consequences of aggregation on cellular function. You will be based in the laboratories of Professors Sheena Radford and Neil Ranson , and work closely with our clinically-qualified collaborators, and where required with other members of the amyloid team (funded by BBSRC, the Royal Society, MRC and Wellcome). You should have a PhD (or be close to completing one) in Structural Biology, Biochemistry, or a related discipline, and you should have extensive experience of using structural methods to elucidate biological mechanisms. Experience in cryo-electron microscopy/tomography would be a significant advantage, but training will be given to outstanding structural biologists lacking this experience but able to evidence their passion and commitment to learn cryo-EM techniques. Further information about the project and our recent publications are available within the additional information document. To explore the post further or for any queries you may have, please contact: Professor Sheena Radford , Astury Professor of Biophysics Tel: 44 (0)113 343 3170 | Email: s.e.radford@leeds.ac.uk Professor Neil A Ranson , Professor of Structural Molecular Biology Tel: 44 (0)113 343 7065 | Email: n.a.ranson@leeds.ac.uk Location: Leeds - Main Campus Faculty/Service: Faculty of Biological Sciences School/Institute: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology Category: Research Grade: Grade 7 Salary: £34,304 to £40,927 p.a. It is unlikely an appointment will be made above £37,467 due to external funding Working Time: 100% Post Type: Full Time Contract Type: Fixed Term (Available on a fixed-term basis for up to 24 months due to external funding) Release Date: Wednesday 11 May 2022 Closing Date: Wednesday 08 June 2022 Interview Date: To be confirmed Reference: FBSAS1053 Downloads: Candidate Brief Additional Information
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