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Position: Postdoctoral Scientist - Bioinformatician
Institution: The Pirbright Institute
Location: Pirbright, Guildford, United Kingdom
Duties: We are looking for a postdoctoral scientist to execute and continue to develop bioinformatics pipelines to analyse transcriptomic data and antibody single cell sequencing data in livestock. This post is funded by a Bill and Melinda Gates Foundation grant aiming to defining the fine specificity of antibody responses in livestock to inform vaccine development. The research will involve refining the analysis of existing and future high-throughput sequencing data to examine the overall antibody response to vaccination and infection in cattle, buffalo, pigs and chickens. Established workflows will then be made available to as wide a range of collaborators as possible
Requirements: A PhD or equivalent in a relevant branch of biosciences; Significant and relevant experience in a recognised R&D environment; Experience with high-throughput sequencing data analysis; Knowledge of Unix and Linux operating systems; Strong experience in at least one programming language; Strong experience in building and deploying distributed pipelines for data science; Excellent oral and written communication skills; A publication records commensurate to the applicant’s career stage
   
Text: We use cookies to enhance your experience on our website. If you continue browsing we'll assume that you are happy to receive cookies. Click here to read about our cookies or to change your cookie settings. Pirbright.logo rgb small transparent180 Search Job Alerts Applications Login Register 21P-131 Postdoctoral Scientist-Bioinformatician Salary: Band E; from £41,181 to £50,421. Candidates are appointed typically at the starting point, with some flexibility subject to skills/knowledge/experience. Our full range of benefits is outlined at the bottom of the job description Hours: 37 hours per week Contract Type: Fixed term/Full time Contract Length: Fixed Term Appointment till 30/09/2024 Closing Date: 26 May 2022 Interview Date: TBC Job Reference: 21P-131 Related Positions 22P-37 Research Scientist or post-doctoral Scientist Salary: Band D; Range £33,671 to £40,693. Candidates are appointed typically at the starting point, with some flexibility subject to skills/knowledge/experience. Hours: 37 hours per week Contract Type: Fixed term/Full time Contract Length: Fixed Term for 1 Year Closing Date: 25 May 2022 Interview Date: TBC Job Reference: 22P-37 21P-131 Postdoctoral Scientist-Bioinformatician Organisation position and purpose: We are looking for a postdoctoral scientist to execute and continue to develop bioinformatics pipelines to analyse transcriptomic data and antibody single cell sequencing data in livestock. This post is funded by a Bill and Melinda Gates Foundation grant aiming to defining the fine specificity of antibody responses in livestock to inform vaccine development. The research will involve refining the analysis of existing and future high-throughput sequencing data to examine the overall antibody response to vaccination and infection in cattle, buffalo, pigs and chickens. Established workflows will then be made available to as wide a range of collaborators as possible. This post will report to the Head of Programme, sitting within the Immunogenetics Group at Pirbright as part of a team focused on measuring the influence of genetic variation on immune responses. Main duties and responsibility Responsible for combining different datasets to identify pathogen-specific immune responses (75%): Characterise and compare antibody transcripts from high-throughput sequencing data obtained with different platforms (Illumina MiSeq and NextSeq; 10X chromium-generated data, occasionally Sanger sequencing), using existing pipelines. Adapt and optimise existing pipelines to multiple livestock species (cattle, buffalo, pigs and chickens). Combine single-cell transcriptomic, antibody NGS sequencing, and mass spectrometry datasets to select B cell antigens of interest and characterize antigen specific B cell subsets. Keep up to date with new pipelines and software. Contribute to a linked team working on structural vaccinology. Integration of analytical tools within the immunological toolbox website (20%): Help maintain the Immunological toolbox website and Pirbright Antibody Hub page. Integrate example datasets on the website. Integrate developed tools for community access. Contribute to the overall Immunogenetics group (5%): Maintain datasets Produce presentations Publish manuscripts as appropriate This job description is only an outline of the tasks, responsibilities and outcomes required of the role. The jobholder will carry out any other duties as may be reasonably required by his/her line manager. The job description and personal specification may be reviewed on an ongoing basis in accordance with the changing needs of The Pirbright Institute. All employees shall actively participate in the Institute-wide quality assurance system in conjunction with the Institute’s Quality Manager. Employees are also expected to safeguard their own health and safety and security by following policies and all employees are responsible for the Health and Safety and security of staff under their management. Personal specification Results driven with a clear ability to drive and organise multiple projects. Good collaboration skills. Attention to detail. Able to problem solve and be creative in generating a solution whilst also able to perform the same activity in a consistent manner. Ability to work independently as well as part of a team in an interdisciplinary environment Critical mind. Specific requirements Essential A PhD or equivalent in a relevant branch of biosciences Significant and relevant experience in a recognised R&D environment Experience with high-throughput sequencing data analysis Knowledge of Unix and Linux operating systems Strong experience in at least one programming language Strong experience in building and deploying distributed pipelines for data science Excellent oral and written communication skills A publication records commensurate to the applicant’s career stage Desirable A good understanding or experience of working with either antibodies or other variable immune genes Experience of molecular biology Experience working with a high-performance cluster Experience in 10X chromium-generated data analysis Experience proteomics data analysis Experience in website development and maintenance Sifting and interviews will be conducted weekly until a successful candidate has been appointed to the position Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances. We would like to encourage all overseas applicants to consider the Tier 1 Global Talent Visa route. This has been designed to offer fast-tracked entry to the UK for scientific researchers to work and live in the UK. Please see for further information under the link: https://www.gov.uk/global-talent What we offer Generous Group Personal Pension Scheme and life cover (subject to age and earnings) Very flexible working pattern including working from home 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days Buy and sell annual leave Option to carry over up to two weeks annual leave Pirbright gym with subsidised membership Pirbright social club Pirbright Lifestyle Hub (employee discount site) Cycle to work Subsidised staff restaurant Childcare allowance Free onsite parking Electric Car charging facilities To apply for this vacancy please visit our careers page -Jobs | The Pirbright Institute The Access Group logo Cookie Policy RSS Feed Pirbright.logo rgb small transparent180 footer As rgb bronze.award130 Facebook40 Twitter40 Linkedin40 Rss40
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