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Position: Doctoral candidate specializing in the field of biochemical measurement sciences
Institution: Physikalisch-Technische Bundesanstalt
Location: Braunschweig, Niedersachsen, Germany
Duties: The comparability of measurement results is essential for establishing an appropriate response to a particular disease prognosis. for the measurement of small clinical biomarkers, the comparability of measurement results is assured by establishing traceability to the International System of Units (SI). for many biomarkers this is achieved by developing high-accuracy reference methods based on the calibration principle of isotope dilution mass spectrometry (IDMS). Recently, this IDMS method has been extended to analyzing proteins in biological matrices. The project aims at assessing different IDMS strategies and evaluating their impact on lowering limits of detection, reducing uncertainty and assessing SI traceability. You will be supporting Working Group 3.22 in the following tasks: Investigation of stable isotope labels combined with mass-spectrometric methods for the quantitative analysis of proteins; Identification of stable protein/peptide markers for the accurate quantification of proteins via unmodified peptides and covalently bound tags; Development of isolation and pre-concentration strategies for the quantification of proteins via organic/inorganic IDMS; Development of reference methods for the accurate quantification of proteins; Determination of the main causes of measurement uncertainty for the developed methods
Requirements: You have completed your university studies (Master's or German Diplom ) in chemistry, biochemistry, biotechnology, chemical analysis or biology with at least the grade "good" You have experience in analyzing and dealing with proteins and IDMS; You have experience with mass-spectrometric protein quantification methods; You have knowledge of bioinformatics and/or peptide sequencing; You have experience with cell culture techniques and/or cellular proteomics; Experience in the field of clinical laboratory medicine is of advantage; Ideally, you are familiar with statistical data analysis and the estimation of measurement uncertainties; You are a strong team player with excellent communication skills; You have a very good command of spoken and written English; You are able to work autonomously and responsibly; You are highly committed and reliable; You are willing to go on business trips within Germany and abroad
   
Text: Doctoral candidate specializing in the field of biochemical measurement sciences (21-437-3) Thursday, 9. December 2021 The Physikalisch-Technische Bundesanstalt (PTB) is the national metrology institute of the Federal Republic of Germany with scientific and technical service tasks. It furthers progress and reliability in metrology for society, the economy and science. With a starting date as soon as possible, Department 3.2, Biochemistry, is looking for a candidate to fill the following position at our Braunschweig site for a duration of three years: Doctoral candidate specializing in the field of biochemical measurement sciences Remuneration Group 13 TVöD Bund (85%) ○ fixed-term contract Your tasks: The comparability of measurement results is essential for establishing an appropriate response to a particular disease prognosis. For the measurement of small clinical biomarkers, the comparability of measurement results is assured by establishing traceability to the International System of Units (SI). For many biomarkers this is achieved by developing high-accuracy reference methods based on the calibration principle of isotope dilution mass spectrometry (IDMS). Recently, this IDMS method has been extended to analyzing proteins in biological matrices. The project aims at assessing different IDMS strategies and evaluating their impact on lowering limits of detection, reducing uncertainty and assessing SI traceability. You will be supporting Working Group 3.22 in the following tasks: Investigation of stable isotope labels combined with mass-spectrometric methods for the quantitative analysis of proteins Identification of stable protein/peptide markers for the accurate quantification of proteins via unmodified peptides and covalently bound tags Development of isolation and pre-concentration strategies for the quantification of proteins via organic/inorganic IDMS Development of reference methods for the accurate quantification of proteins Determination of the main causes of measurement uncertainty for the developed methods Your profile: You have completed your university studies (Master's or German Diplom ) in chemistry, biochemistry, biotechnology, chemical analysis or biology with at least the grade "good" You have experience in analyzing and dealing with proteins and IDMS You have experience with mass-spectrometric protein quantification methods You have knowledge of bioinformatics and/or peptide sequencing You have experience with cell culture techniques and/or cellular proteomics Experience in the field of clinical laboratory medicine is of advantage Ideally, you are familiar with statistical data analysis and the estimation of measurement uncertainties You are a strong team player with excellent communication skills You have a very good command of spoken and written English You are able to work autonomously and responsibly You are highly committed and reliable You are willing to go on business trips within Germany and abroad We offer: A position at one of the world’s leading research institutions with an excellent infrastructure Intensive PhD supervision in an interdisciplinary team Excellent national and international connections Remuneration in accordance with the collective bargaining agreement for the public service ( Tarifvertrag öffentlicher Dienst Bund - TVöD for the federal level) Various workplace health and wellness options Basic and advanced training opportunities In-house daycare center and canteen Good transport connections (bus and bike); free parking You will find further information related to this position in Department 3.2 and by contacting: Dr. C. Swart, phone: 49 531 592-3320, E-mail: claudia.swart (at) ptb . de or Prof. Dr. G. O‘Connor, phone: 49 531 592-3200, E-mail: gavin.oconnor (at) ptb . de . PTB promotes the professional equality of women and men and is thus especially interested in applications from women. Within the scope of the official feasibilities, PTB offers flexible part-time work schemes in order to support in particular the compatibility of work and family life. Disabled persons will be given priority if they have the same occupational aptitude. Please use our online application form Alternatively, you can post your application to us at the following address: Physikalisch-Technische Bundesanstalt Referat "Personal" Reference number 21-437-3 Bundesallee 100 38116 Braunschweig Germany Unfortunately, we cannot accept applications sent via e-mail. Applications can be submitted from 18 November 2021 until 9 December 2021. Back
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