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Position: Research Fellow (Investigating Synaptic Biology in ALS)
Institution: University College London
Department: UCL Queen Square Institute of Neurology - Department of Neuromuscular Diseases
Location: London, United Kingdom
Duties: The Department of Neuromuscular Diseases is a hub for clinical and research excellence across the spectrum of spinal cord and neuromuscular diseases. We are looking for a Research Fellow to join the Fratta Lab, which uses human iPSC-derived neurons, mouse models and post mortem tissue to investigate the pathogenesis of amyotrophic lateral sclerosis (ALS). The project will involve both imaging and electrophysiology investigations in iPSC-derived neurons and also testing of novel therapeutic targets for this incurable disease. The Research Fellow will investigate how TDP-43 loss of function induces synaptic dysfunction and neurodegeneration in ALS, and the role UNC13A reduction plays in this ALS pathogenesis
Requirements: The successful candidate must have a PhD in Neuroscience/biological science, and experience with neuronal cell culture and in confocal imaging. The ability to present research findings with authority and coherence to a variety of audiences at national and international conferences, seminars and project meetings is essential, as are excellent oral and written communication skills. Strong problem solving abilities, and good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting and in a diverse group including computational and experimental neurobiologists are also required. Experience with iPSCs, molecular biology and cloning is desirable
   
Text: Research Fellow (Investigating Synaptic Biology in ALS), - Ref:1878761 Click here to go back to search results Apply Now UCL Department / Division UCL Queen Square Institute of Neurology Specific unit / Sub department Department of Neuromuscular Diseases Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,770 - £44,388 per annum Duties and Responsibilities The Department of Neuromuscular Diseases is a hub for clinical and research excellence across the spectrum of spinal cord and neuromuscular diseases. We are looking for a Research Fellow to join the Fratta Lab, which uses human iPSC-derived neurons, mouse models and post mortem tissue to investigate the pathogenesis of amyotrophic lateral sclerosis (ALS). The project will involve both imaging and electrophysiology investigations in iPSC-derived neurons and also testing of novel therapeutic targets for this incurable disease. The Research Fellow will investigate how TDP-43 loss of function induces synaptic dysfunction and neurodegeneration in ALS, and the role UNC13A reduction plays in this ALS pathogenesis. The post is available immediately and is funded by a grant from the UK Medical Research Council for 24 months in the first instance. Key Requirements The successful candidate must have a PhD in Neuroscience/biological science, and experience with neuronal cell culture and in confocal imaging. The ability to present research findings with authority and coherence to a variety of audiences at national and international conferences, seminars and project meetings is essential, as are excellent oral and written communication skills. Strong problem solving abilities, and good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting and in a diverse group including computational and experimental neurobiologists are also required. Experience with iPSCs, molecular biology and cloning is desirable. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £32,217 - £33,958 per annum, pro-rata for part-time post, including London Allowance) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis. Further Details A Job Description and Person Specification can be accessed at the bottom of this page. To apply for the vacancy, please click on the 'Apply Now' button below. If you have any queries regarding the application process, please contact Oksana Shapoval, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk). For further queries, please contact p.fratta@ucl.ac.uk. UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 1 Oct 2021 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job description and Person specification Apply Now
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