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Position: Postdoctoral researcher in Ubiquitin Signalling (biochemistry and mechanisms of stress and inflammation signalling)
Institution: Technical University of Denmark
Location: Kongens Lyngby, Lyngby‐Taarbæk Municipality, Denmark
Duties: The postdoc will pioneer the development of new tools for deciphering atypical ubiquitin chain signalling, including M1-linked/linear chains, to understand how these ubiquitin modifications control cell signalling. The project will involve experimental laboratory work using nanobody discovery and phage display technologies, molecular cloning, protein biochemistry, recombinant protein expression, in vitro assays, molecular cell biology, and cell culture systems to develop new techniques and tools to study the function of the enigmatic atypical ubiquitin modifications in cells. The project may also include cutting-edge mass spectrometry-based proteomics analyses performed in collaboration with the DTU Proteomics Core
Requirements: PhD degree in biochemistry, molecular biology, or similar field; Strong background in biochemistry, molecular biology, and experimental design/assay development; Solid, demonstrated experience in protein biochemistry, including recombinant protein design, expression, and purification; Demonstrated experience in molecular biology, including PCR and molecular cloning, gel electrophoresis, and DNA sequencing; Demonstrated experience in in vitro enzymatic assays
   
Text: Postdoctoral researcher in Ubiquitin Signalling (biochemistry and mechanisms of stress and inflammation signalling) DTU Bioengineering Share on Facebook Share on Twitter Share on Linkedin Monday 07 Jun 21 Apply for this job Apply no later than 12 July 2021 Apply for the job at DTU Bioengineering by completing the following form. Apply online A 2-year postdoc position in ubiquitin signalling is available from 1 September 2021 or shortly thereafter (starting date can be negotiated) in the laboratory of Associate Professor Rune Busk Damgaard .The project is funded by the Novo Nordisk Foundation and the successful candidate will join an ambitious and international research team at the Department of Biotechnology and Biomedicine, Technical University of Denmark. Research in the Ubiquitin Signalling and Inflammation Lab aims at understanding how cell signalling, particularly at the interface of inflammation, cell death, and metabolism, is regulated by ubiquitin modifications and how dysregulation of these signalling mechanisms leads to disease development, including autoinflammatory diseases and cancer. A particular focus of the lab is to explore and understand the cellular functions of the enigmatic 'atypical' ubiquitin chains. Our long-term goal is to discover new signalling mechanism and identify molecular processes that can be targeted pharmacologically to treat cancer and other diseases caused by chronic or dysregulated inflammation. Responsibilities and qualifications The postdoc will pioneer the development of new tools for deciphering atypical ubiquitin chain signalling, including M1-linked/linear chains, to understand how these ubiquitin modifications control cell signalling. The project will involve experimental laboratory work using nanobody discovery and phage display technologies, molecular cloning, protein biochemistry, recombinant protein expression, in vitro assays, molecular cell biology, and cell culture systems to develop new techniques and tools to study the function of the enigmatic atypical ubiquitin modifications in cells. The project may also include cutting-edge mass spectrometry-based proteomics analyses performed in collaboration with the DTU Proteomics Core. We are looking for a talented, curious, and highly motivated a candidate with the following qualifications and experience for this ambitious and pioneering project: Essential skills: PhD degree in biochemistry, molecular biology, or similar field Strong background in biochemistry, molecular biology, and experimental design / assay development Solid, demonstrated experience in protein biochemistry, including recombinant protein design, expression, and purification Demonstrated experience in molecular biology, including PCR and molecular cloning, gel electrophoresis, and DNA sequencing Demonstrated experience in in vitro enzymatic assays Desirable skills: Experience with ubiquitin signalling, protein quality control, or cell stress Experience with analysis of cell signalling and multiprotein complexes (e.g. immunoprecipitation and pulldowns, western blotting, etc.) Experience with phage display technologies or nanobody discovery Experience with mammalian cell culture and cell biology Experience with flow cytometry Experience with genome editing (e.g. CRISPR/Cas9) Experience with mass spectrometry-based proteomics The successful candidate should thrive in a highly ambitious research group and will have demonstrated the ability to work independently and a documented track record of publication in internationally recognised peer-reviewed journals. Good communication skills in both written and spoken English are a requirement. We offer The Ubiquitin Signalling and Inflammation Lab offers a highly ambitious, exciting, encouraging, and dynamic work environment. Together, we design and execute experiments that lead to discovery of new signalling mechanisms involved in development of inflammatory disease and cancer. We work together in a young and fun team. We grow together as scientists to tackle important, fundamental research questions. Read more about the lab and our research here: http://bioengineering.dtu.dk/usi The Ubiquitin Signalling and Inflammation lab is part of the Department of Biotechnology and Biomedicine, Technical University of Denmark. The department is highly interdisciplinary and a leading department within life sciences in Denmark, covering both fundamental, technological, and applied aspects of biomedical research. The successful candidate will join a recently started lab with excellent funding and support from Novo Nordisk Foundation, Lundbeck Foundation, and DTU. The candidate will benefit from a thriving international and collaborative community and state-of-the-art facilities with access to cutting-edge technologies and equipment. DTU is a leading technical university globally recognised for the excellence of its research, education, innovation, and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterised by collegial respect and academic freedom tempered by responsibility. Assessment The assessment of the applicants will be made by Associate Professor Rune Busk Damgaard together with relevant project partners. Applications will be assessed on a rolling basis. Salary and terms of employment The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. This is a full-time position. The start date is 1 September 2021 or as negotiated. The position is for 2 years in the first instance. The maximum employment period as a postdoc is 4 years. The laboratory is located at DTU Lyngby Campus (Greater Copenhagen, Denmark). Further information Informal enquiries and requests for further information should be directed to Associate Professor Rune Busk Damgaard ( rudam@dtu.dk ) If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU - Moving to Denmark . Application procedure Please submit your online application no later than 12 July 2021 . Applications must be submitted as a single PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file . The file must include: Application (cover letter) CV List of publications Academic diplomas (PhD, or MSc diploma if PhD degree has not been conferred) Names and contact details for two academic references Applications and enclosures received after the deadline will not be considered. All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply. Technology for people DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
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