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Position: Research Fellow
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: Our objective is to provide a comprehensive mapping of the genetic factors and biological processes that cause α-synuclein driven Parkinson’s disease (PD). Our strategy is based on four steps: (1) We will generate a map of the PD brain at unprecedented resolution using α-synuclein oligomers as biomarkers; (2) We will then use this map to find the cells undergoing the earliest damage, and perform single-cell transcriptomics/genomics, (3) We will analyse these data to identify the genes and pathways leading to disease, revealing why susceptible cells die and resistant cells are spared, and (4) we will validate the most relevant genes and processes through induced pluripotent stem cell studies. Our results will redefine the textbooks by mapping the PD brain through α-synuclein oligomers, rather than through Lewy bodies
Requirements: Candidate must have PhD in Neuroscience, Biostatistics, Mathematics, Physics or related discipline, experience with computational biology, ideally high throughout sequence data analysis and using programming languages: R and/or python. Knowledge and experience of single nucleus RNA-sequencing data analysis and its use and knowledge and experience of bulk tissue RNA-sequencing data analysis are desirable. Candidate will be proficient in using current tools and databases such as UCSC Genome Browser, ExAC/gnomAD, ClinVar, UniProt and others, proficient with the use of cluster computing
   
Text: Research Fellow, - Ref:1876044 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £38,015 per annum Duties and Responsibilities This is an outstanding opportunity to work independently on a newly funded project from a grant from the Aligning Science across Parkinsons (ASAP) Administered by the Michael J Fox Foundation For Parkinsons Research. Our objective is to provide a comprehensive mapping of the genetic factors and biological processes that cause α-synuclein driven Parkinsons disease (PD). Our strategy is based on four steps: (1) We will generate a map of the PD brain at unprecedented resolution using α-synuclein oligomers as biomarkers; (2) We will then use this map to find the cells undergoing the earliest damage, and perform single-cell transcriptomics/genomics, (3) We will analyse these data to identify the genes and pathways leading to disease, revealing why susceptible cells die and resistant cells are spared, and (4) we will validate the most relevant genes and processes through induced pluripotent stem cell studies. Our results will redefine the textbooks by mapping the PD brain through α-synuclein oligomers, rather than through Lewy bodies. The successful candidate will be primarily responsible for building and implementing the pipeline for single nuclear RNA sequencing and ATACseq. We also plan to establish state of the art spatial transcriptomics, eg MERFish, SlideSeq and other techniques as they emerge. This post is funded until 31 December 2023 in the first instance. Key Requirements Candidate must have PhD in Neuroscience, Biostatistics, Mathematics, Physics or related discipline, experience with computational biology, ideally high throughout sequence data analysis and using programming languages: R and/or python. Knowledge and experience of single nucleus RNA-sequencing data analysis and its use and knowledge and experience of bulk tissue RNA-sequencing data analysis are desirable. Candidate will be proficient in using current tools and databases such as UCSC Genome Browser, ExAC/gnomAD, ClinVar, UniProt and others, proficient with the use of cluster computing. Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £31,542 - £33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections) and once PhD has been awarded. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference 1876044. UCL Taking Action for Equality Closing Date 2 Jun 2021 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Gold award, in recognition of our long-term commitment and 'beacon' status in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job description and Person specification Apply Now
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