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Position: Research Fellow in T-cell Bioprocessing and Biomanufacturing
Institution: University College London
Department: Biochemical Engineering
Location: London, United Kingdom
Duties: The Research Fellow, under the supervision of Dr Qasim Rafiq, will lead the bioprocessing and biomanufacture of CAR-T immunotherapies within the AIDPATH project, with a focus on the production in bioreactors and integration of non-viral technologies. The role will require extensive collaboration with key EU partners and extensive cell culture and bioreactor studies to generate novel datasets. This may include studies focused on T-cell isolation and characterisation of donor variability, in addition to their upstream/downstream processing, characterisation and cellular analysis
Requirements: To succeed in this role you will have a PhD awarded (or about to be) in a relevant subject. This may include biological sciences, cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to T-cell and/or mammalian applications. Experience of mammalian cell culture (irrespective of cell type), including expansion and cell characterisation. Training and experience in working with primary T-cells, including their isolation, expansion and analysis
   
Text: Research Fellow in T-cell Bioprocessing and Biomanufacturing , - Ref:1875654 Click here to go back to search results Apply Now UCL Department / Division Biochemical Engineering Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £43,533 per annum Duties and Responsibilities We are seeking to recruit a proactive, collaborative, dedicated, well organised, highly motivated, and driven Research Fellow to join the Cell and Gene Therapy Bioprocessing Group at UCL within the Department of Biochemical Engineering and lead the T-cell bioprocessing and biomanufacturing research on the EU Horizon 2020 AIDPATH Project. AIDPATH (Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital), is a high-energy EU consortium, dedicated to enable and to augment the next-generation of personalized medicine with gene-engineered immune cells (CAR-T therapy) at EU hospitals through the use of AI technology. The Research Fellow will lead the lead the bioprocessing and biomanufacturing research associated with the optimisation and development of personalised T-cell therapies. The Research Fellow, under the supervision of Dr Qasim Rafiq, will lead the bioprocessing and biomanufacture of CAR-T immunotherapies within the AIDPATH project, with a focus on the production in bioreactors and integration of non-viral technologies. The role will require extensive collaboration with key EU partners and extensive cell culture and bioreactor studies to generate novel datasets. This may include studies focused on T-cell isolation and characterisation of donor variability, in addition to their upstream/downstream processing, characterisation and cellular analysis. As the AIDPATH Research Fellow you will devise and undertake appropriate experiments to achieve the goals and milestones as described in the research programme, submitted to the sponsor. This would include a significant element of independent work, e.g. in the planning and execution of experiments, and the write up of work for publication. Interact with the researchers, PDRAs and investigators within the Cell and Gene Therapy Bioprocess Group at UCL and all personnel involved in the AIDPATH project at the European collaborators to successfully deliver the project. Write regular reports to the supervisor, compile data acquired in a form to allow rapid transformation of documented research results into high quality research papers and/or patent applications, communicate the results during regular meetings. Maintain an up to date/detailed log of the research activity undertaken and of the results obtained. The post is funded for 3 years in the first instance. Key Requirements To succeed in this role you will have a PhD awarded (or about to be) in a relevant subject. This may include biological sciences, cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to T-cell and/or mammalian applications. Experience of mammalian cell culture (irrespective of cell type), including expansion and cell characterisation. Training and experience in working with primary T-cells, including their isolation, expansion and analysis. Experience of working with different cell culture platforms and bioreactors (e.g. Stirred-tank bioreactors, Miltenyi Prodigy, Lonza Cocoon, Hollow-fibre bioreactors, Rocking Motion systems), experience with cell characterisation assays including flow cytometry, ELISA, qPCR and other relevant assays for T-cell culture. Ability to use creative problem-solving skills to independently design experiments and troubleshoot experimental challenges, able to perform studies accurately and reproducibly, accomplish project objectives, and meet or exceed expectations while effectively contributing to the team. You should have genuine passion and commitment for the development of innovative solutions to T-cell immunotherapies, be positively-minded and solution focused. Cell and Gene Therapy Bioprocessing Group The Cell and Gene Therapy Bioprocessing Group within the UCL Department of Biochemical Engineering focuses on addressing research challenges associated with the translation, manufacture and delivery of regenerative medicines and cell and gene therapies. Our core research is focus on expediting and accelerating the development, commercialisation and adoption of these therapies with the aim of making advanced therapies widely accessible. We believe that the translational and manufacturing challenges need to be addressed in order to make these therapies cost effective and are driven by this goal. Our group members, including research students, research associates and investigators are collectively driven by high impact work and are passionate about delivering the high quality research that will deliver solutions to current problems. We do not compromise on our goal to establish a high performing, innovative and collaborative team environment and we believe in recruiting and developing the best researchers available within the field. We set ourselves high standards, ensure that the work we do keeps up with the fast pace across industry and academia, and we support each other to ensure we get the best out of each team member and the group as a whole. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy, please click on the Apply Now button below. If you have any queries regarding the application process, please contact Dr Qasim Rafiq q.rafiq@ucl.ac.uk. UCL Taking Action for Equality Closing Date 4 May 2021 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. Job description and Person specification Apply Now
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