www.acad.jobs : academic jobs worldwide – and the best jobs in industry
                
     
Position: Research Fellow
Institution: University College London
Department: Infection and Immunity - Institute of Immunity and Transplantation
Location: London, United Kingdom
Duties: Applications are invited for a Post Doctoral Research Fellow position in the UCL Institute of Immunity and Transplantation in a research team led by Professor Benedict Seddon. The post is funded by a collaborative grant from AstraZeneca "Tracking fate and function of FOXP3 ASO treated "ex-Tregs" in Vivo". Regulatory T-cells (Treg) are immunosuppressive cells that maintain self-tolerance, but are also overrepresented in the tumour microenvironment and prevent anti-tumour immunity. FOXP3 antisense oligonucleotides (ASOs) inhibit expression of FOXP3 that is required for Treg suppressive fuction and are under consideration as a therapeutic treatment to promote anti-tumour responsiveness. The fate of targeted Treg remains unknown, however
Requirements: The postholder should have a PhD (or about to be awarded) in a relevant subject. The successful candidates must have significant experience of working in a research laboratory. Evidence of scientific contribution including publications and presentation at conferences is also essential. Candidates must have excellent oral and written scientific communications skills, commitment to collaboration in research and to taking a multidisciplinary approach to problem solving
   
Text: Research Fellow, - Ref:1872647 Click here to go back to search results Apply Now UCL Department / Division Infection and Immunity Specific unit / Sub department Institute of Immunity and Transplantation Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £43,533 per annum Duties and Responsibilities Applications are invited for a Post Doctoral Research Fellow position in the UCL Institute of Immunity and Transplantation in a research team led by Professor Benedict Seddon. The post is funded by a collaborative grant from AstraZeneca "Tracking fate and function of FOXP3 ASO treated "ex-Tregs" in Vivo". Regulatory T-cells (Treg) are immunosuppressive cells that maintain self-tolerance, but are also overrepresented in the tumour microenvironment and prevent anti-tumour immunity. FOXP3 antisense oligonucleotides (ASOs) inhibit expression of FOXP3 that is required for Treg suppressive fuction and are under consideration as a therapeutic treatment to promote anti-tumour responsiveness. The fate of targeted Treg remains unknown, however. A key aim of this project is to employ FoxP3 fate reporter systems in mice to understand which Treg are targeted by ASO, and the fate of cells following treatment. Also, we wish to understand the impact of Treg inhibition upon T cell compartment composition and function. The post-holder will be expected to perform the highest quality research under the direction of the Principal Investigator, and to work effectively with external collaborators involved in the project and other group members. Prof. Seddon directs an interdisciplinary team, including molecular and cellular immunologists. Key research goals are to gain a greater understanding of how homeostasis and function of different T cell compartments is maintained throughout the life course. The position is funded until the 31st December 2022 in the first instance. The position will suit a motivated postdoctoral scientist who wishes to develop their career and pursue opportunities for independent fellowships. See https://www.ucl.ac.uk/immunity-transplantation/about/people/benedict-seddon for further background information. Key Requirements The postholder should have a PhD (or about to be awarded) in a relevant subject. The successful candidates must have significant experience of working in a research laboratory. Evidence of scientific contribution including publications and presentation at conferences is also essential. Candidates must have excellent oral and written scientific communications skills, commitment to collaboration in research and to taking a multidisciplinary approach to problem solving. Note: Appointment at grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at the Research Assistant Grade 6B (salary £31,542 - £33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the Apply Now button below. Informal enquiries regarding the vacancy can be made by email to Professor Benedict Seddon at benedict.seddon@ucl.ac.uk . If you have any queries regarding the application process, please contact Isabel Lubeiro at i.lubeiro@ucl.ac.uk . UCL Taking Action for Equality Closing Date 10 Feb 2021 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description & Person Specification Apply Now
Please click here, if the job didn't load correctly.
Your browser does not support iframes. Please click <a href="https://www.acad.jobs/job.php?t_id=J000342405&redirect" target="_parent" style="color:#7A7A7A">here</a>, if the job didn't load correctly.