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Position: Postdoctoral Researcher in Molecular and Functional Neurobiology Group
Institution: University of Luxembourg
Location: Luxembourg City, Luxembourg
Duties: The postdoctoral fellow will be involved in the ATTRACT project entitled: “Modelling idiopathic Parkinson’s disease-associated somatic variation in dopaminergic neurons”. The aim of this FNR-funded research we aim to investigate the involvement of the mitochondrial genome in the pathogenesis of Parkinson's disease using stem cell-derived cellular models and postmortem brain tissue. Your tasks/mission: Generation/maintenance of induced pluripotent stem cells and subsequent differentiation into dopaminergic neurons and astrocytes; Design and application of experiments to assess the impact of mtDNA maintenance defects on mitochondrial, neuronal and astrocyte function; Evaluation of the immune reactivity of mature astrocytes; Application of transcriptomics and metabolomics approaches to iPSC-derived models; Student supervision
Requirements: PhD in Cellular Biology, Molecular Biology, Neuroscience, or related discipline; Strong interest in interdisciplinary research and cellular models of neurodegeneration; Track record in research and laboratory work as documented by publications in internationally acknowledged journals; Profound knowledge of molecular genetics, biochemistry and cell biology; Expertise with inducible pluripotent stem cell models, especially neuronal and astroglia differentiation protocols; Experience in metabolic analysis using mass spectrometry; Previous experience with CRISPR/Cas9 gene editing desirable; Excellent communication, team-working and interpersonal skills; Previous experience as supervisor of students; Enthusiasm and great commitment to research; Very good command of the English language; We offer: Fully funded position with the possibility of renewal for up to 5 years depending on availability of funding; Exciting international research environment; Opportunity to participate in the development of the LCSB; Travel opportunities to national and international meetings as well as participation in specialized trainings; The University of Luxembourg offers highly competitive salaries and is an equal opportunity employer
   
Text: UOL03741 31-Dec-2099 About the University The University of Luxembourg aspires to be one of Europe’s most highly regarded universities with a distinctly international and interdisciplinary character . It fosters the cross-fertilisation of research and teaching , is relevant to its country, is known worldwide for its research and teaching in targeted areas, and is establishing itself as an innovative model for contemporary European Higher Education. It`s core asset is its well-connected world-class academic staff which will attract the most motivated, talented and creative students and young researchers who will learn to enjoy taking up challenges and develop into visionary thinkers able to shape society. Within the University, the Luxembourg Centre for Systems Biomedicine (LCSB) is a highly interdisciplinary research centre (IC), integrating experimental biology and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalized medicine. Your Role The postdoctoral fellow will be involved in the ATTRACT project entitled : “Modelling idiopathic Parkinson’s disease-associated somatic variation in dopaminergic neurons” . The aim of this FNR-funded research we aim to investigate the involvement of the mitochondrial genome in the pathogenesis of Parkinson's disease using stem cell-derived cellular models and postmortem brain tissue. Your tasks/mission: Generation/maintenance of induced pluripotent stem cells and subsequent differentiation into dopaminergic neurons and astrocytes Design and application of experiments to assess the impact of mtDNA maintenance defects on mitochondrial, neuronal and astrocyte function Evaluation of the immune reactivity of mature astrocytes Application of transcriptomics and metabolomics approaches to iPSC-derived models Student supervision Your Profile PhD in Cellular Biology, Molecular Biology, Neuroscience, or related discipline Strong interest in interdisciplinary research and cellular models of neurodegeneration Track record in research and laboratory work as documented by publications in internationally acknowledged journals Profound knowledge of molecular genetics, biochemistry and cell biology Expertise with inducible pluripotent stem cell models, especially neuronal and astroglia differentiation protocols Experience in metabolic analysis using mass spectrometry Previous experience with CRISPR/Cas9 gene editing desirable Excellent communication, team-working and interpersonal skills Previous experience as supervisor of students Enthusiasm and great commitment to research Very good command of the English language We offer: Fully funded position with the possibility of renewal for up to 5 years depending on availability of funding Exciting international research environment Opportunity to participate in the development of the LCSB Travel opportunities to national and international meetings as well as participation in specialized trainings The University of Luxembourg offers highly competitive salaries and is an equal opportunity employer In Short Contract Type: Fixed Term Contract 24 Month Work Hours: Full Time 40.0 Hours per Week Location: Belval Job Reference: UOL03741 Further Information Applications (in English) should contain the following documents: Detailed Curriculum Vitae including a list of publications Cover letter mentioning the reference number Description of past research experience and future interests Copies of diploma and transcripts Name and addresses of three referees Early application is highly encouraged, as the applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by email will not be considered. The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. Here’s what awaits you at the University Multilingual and international character . Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR). A modern and dynamic university. High-quality equipment. WiFi on campus. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure. A partner for society and industry . Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs … Find out more about the University Addresses, maps & routes to the various sites of the University Further information For further information, please contact Prof. A. Grünewald at anne.gruenewald@uni.lu
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