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Position: Research Fellow UK Dementia Research Institute
Institution: University College London
Department: Uk Dri
Location: London, United Kingdom
Duties: Dementia is the greatest health challenge of our century; To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it; The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap. Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test; The Bartels lab at the UK DRI at UCL is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank. The Bartels laboratory is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients; Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinsons Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity; The Bartels lab at the UK DRI at UCL is seeking a Research Fellow. Duties will include testing antibody panels for specificity towards different forms of α-Synuclein, developing an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establishing a fluid biomarker for Parkinsons Disease and Dementia with Lewy Bodies; The project will be conducted in collaboration with the Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery in Queen Square London; Duration of the post is available from December 2020 and is funded by UK DRI at UCL for 1 year in the first instance
Requirements: Applicants should have a PhD, MD or equivalent experience in Biophysics, Biochemistry, Molecular Biology or related discipline. Experience of working in quantitative biological analytistics (ELISA, Quanterix) and with antibody development and verification is essential; IT proficiency at advanced user level, the ability to present complex scientific concepts, and an understanding of the mission of the UK DRI is also a requirement, as is the ability to be a creative and proactive thinker. Experience with handling human samples, with biomarker development, and of working with Biophysics/Biochemistry/Molecular Biology/Histology assays is desirable
   
Text: Research Fellow UK Dementia Research Institute, - Ref:1873223 Click here to go back to search results Apply Now UCL Department / Division UK DRI Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £43,533 per annum Duties and Responsibilities Dementia is the greatest health challenge of our century. To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it. The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap. Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test. The Bartels lab at the UK DRI at UCL is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank. The Bartels laboratory is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients. Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinsons Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity. The Bartels lab at the UK DRI at UCL is seeking a Research Fellow. Duties will include testing antibody panels for specificity towards different forms of α-Synuclein, developing an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establishing a fluid biomarker for Parkinsons Disease and Dementia with Lewy Bodies. The project will be conducted in collaboration with the Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery in Queen Square London. Duration of the post is available from December 2020 and is funded by UK DRI at UCL for 1 year in the first instance. Key Requirements Applicants should have a PhD, MD or equivalent experience in Biophysics, Biochemistry, Molecular Biology or related discipline. Experience of working in quantitative biological analytistics (ELISA, Quanterix) and with antibody development and verification is essential. IT proficiency at advanced user level, the ability to present complex scientific concepts, and an understanding of the mission of the UK DRI is also a requirement, as is the ability to be a creative and proactive thinker. Experience with handling human samples, with biomarker development, and of working with Biophysics/Biochemistry/Molecular Biology/Histology assays is desirable. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,542 - £33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis. Further Details A job description and full person specification can be accessed below. To apply for the vacancy, please click the Apply Now button below. For informal enquiries about the role please contact Dr Tim Bartels (t.bartels@ucl.ac.uk). If you have any queries regarding the the application process, please contact Samantha Robinson, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk). UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 15 Dec 2020 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description Apply Now
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