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Position: Research Fellow - Bioinformatician
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: We are seeking a talented and highly motivated computational biology postdoc to join the research group of Prof Adrian Thrasher and Dr Giandomenico Turchiano at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology; Gene therapies are showing an increasing success in clinical trials and they are continuously evolving towards new tools for genetic manipulation. Despite the great advantages, a better characterization of the genotoxicity effects is crucial for delivering safe and efficient therapies. We aim to apply existing and develop new techniques and analysis tools in order to characterize all the possible mutations and effects on primary cells and patient samples treated with lentiviral gene therapy and/or gene editing tools; The successful candidate will contribute to the design and development of such techniques, leading the analyses and interpretation of the genotoxicity data. The post holder will work in an international and highly collaborative environment, benefiting from the expertise of both academia and industry in the field of gene editing, stem cell manipulation, genetics and computational biology; Duration of the post is for 24 months in the first instance
Requirements: Applicants must have PhD degree in a relevant subject. We are seeking a curious and talented researcher with a prime interest in gene editing and genomics; Candidates should have strong programming skills with a PhD in bioinformatics, computational biology, statistics or related genomic disciplines and should have prior experience with next-generation sequencing data, translational bioinformatics, data-mining of large scale genomic datasets and databases. Previous experience with RNA-seq, LM/LAM-PCR data analysis is a plus
   
Text: Research Fellow - Bioinformatician, - Ref:1872803 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £37,008 per annum Duties and Responsibilities We are seeking a talented and highly motivated computational biology postdoc to join the research group of Prof Adrian Thrasher and Dr Giandomenico Turchiano at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology (https://www.ucl.ac.uk/child-health/research/infection-immunity-inflammation/molecular-and-cellular-immunology). Gene therapies are showing an increasing success in clinical trials and they are continuously evolving towards new tools for genetic manipulation. Despite the great advantages, a better characterization of the genotoxicity effects is crucial for delivering safe and efficient therapies. We aim to apply existing and develop new techniques and analysis tools in order to characterize all the possible mutations and effects on primary cells and patient samples treated with lentiviral gene therapy and/or gene editing tools. The successful candidate will contribute to the design and development of such techniques, leading the analyses and interpretation of the genotoxicity data. The post holder will work in an international and highly collaborative environment, benefiting from the expertise of both academia and industry in the field of gene editing, stem cell manipulation, genetics and computational biology. Duration of the post is for 24 months in the first instance. Key Requirements Applicants must have PhD degree in a relevant subject. We are seeking a curious and talented researcher with a prime interest in gene editing and genomics. Candidates should have strong programming skills with a PhD in bioinformatics, computational biology, statistics or related genomic disciplines and should have prior experience with next-generation sequencing data, translational bioinformatics, data-mining of large scale genomic datasets and databases. Previous experience with RNA-seq, LM/LAM-PCR data analysis is a plus. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference 1872803. UCL Taking Action for Equality Closing Date 21 Nov 2020 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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