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Position: Research Fellow
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: The appointee will join our dermatology and gene therapy research groups within the programme to develop novel gene therapy strategies for the treatment of inherited skin diseases. You will carry out subcloning, prepare plasmid DNA and make viral vector stocks, perform tissue culture including keratinocytes/fibroblasts and single cell culture and bio-engineered skin sheet and to transduce cells and evaluate the efficiency of gene editing using different reagents and condition; You will use gene editing approach for the skin disease Netherton syndrome (NS), a debilitating genetic condition occurring at or soon after birth using. Following the delivery of gene editing reagents, the efficacy of gene editing therapy will be assessed in in-vitro and in-vivo models. Our ultimate aim is to use NS as a disease model to develop a gene editing platform for wide range of genetic skin conditions; Duration of the post is funded for 18 months in the first instance
Requirements: Applicants should have a PhD in Molecular Biology or related field. Experience in molecular biology is essential and techniques in cell culture, viral vector preparation and animal handling would be advantageous. The candidate must have an ability to work collaboratively as part of a team and be able to function independently and effectively with appropriate supervision. A track record based on publications and presentation is desirable
   
Text: Research Fellow, - Ref:1872590 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 per annum Duties and Responsibilities The appointee will join our dermatology and gene therapy research groups within the programme to develop novel gene therapy strategies for the treatment of inherited skin diseases. You will carry out subcloning, prepare plasmid DNA and make viral vector stocks, perform tissue culture including keratinocytes/fibroblasts and single cell culture and bio-engineered skin sheet and to transduce cells and evaluate the efficiency of gene editing using different reagents and condition. You will use gene editing approach for the skin disease Netherton syndrome (NS), a debilitating genetic condition occurring at or soon after birth using. Following the delivery of gene editing reagents, the efficacy of gene editing therapy will be assessed in in-vitro and in-vivo models. Our ultimate aim is to use NS as a disease model to develop a gene editing platform for wide range of genetic skin conditions. Duration of the post is funded for 18 months in the first instance. Key Requirements Applicants should have a PhD in Molecular Biology or related field. Experience in molecular biology is essential and techniques in cell culture, viral vector preparation and animal handling would be advantageous. The candidate must have an ability to work collaboratively as part of a team and be able to function independently and effectively with appropriate supervision. A track record based on publications and presentation is desirable. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the vacancy or the application process, please contact Madhur Sharma on Ich.hr@ucl.ac.uk, Tel: 020 7905 2742 quoting job reference. UCL Taking Action for Equality Closing Date 5 Nov 2020 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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