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Position: Postdoctoral researcher in Translational Neuroscience
Institution: University of Luxembourg
Location: Luxembourg City, Luxembourg
Duties: The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval. The Translational Neuroscience Group, led by Prof Rejko Krueger, creates a translational bridge between fundamental and the clinic with a focuse on Parkinson’s disease research, with the aim to improve diagnosis and therapy to help patients in Luxembourg and beyond. We are currently looking for an energetic, highly motivated post-doctoral researcher for a collaborative fundamental biology research project in Parkinson’s Disease (PD). Tasks/Activities The post-doctoral researcher will contribute to relevant projects of the Translational Neuroscience Group, in particular to the investigation of the role of different models of α-syn pathogenicity in PD The aim of this project is to characterize patient-based cellular models, e.g. using induced pluripotent stem cells to gain essential knowledge with respect to the molecular mechanisms involved in the pathogenesis of PD. These models then will be explored for serving as cellular readouts for genetic and pharmacological modifications to revert disease associated phenotypes and to disentangle functional networks related to neurodegeneration. Specific tasks can include: conduct research processes to achieve the goals of the project in an interdisciplinary team approach; develop methodologies and integrate new technologies; collect, assemble and evaluate research data; analyses and interpretation of results obtained; writing scientific publications and grant applications; contribution to research reports; perform advanced molecular and cellular biological experiments such as cloning, gene-editing (CrisPR), qPCR; generation of viral expression constructs and transduction of patient based cellular models; perform various biochemical assays and protein purifications; culture of induced pluripotent stem cells (iPSC) into different CNS-related cell types including 3D cultures (organoids); development and application of functional readouts for different mitochondrial and neuronal phenotypes; presenting the results at national and international scientific meetings as posters or talks
Requirements: PhD in Cellular Biology, Neuroscience, or related discipline; strong interest in interdisciplinary research and cellular models of neurodegeneration; experience in research and laboratory work; profound knowledge of molecular genetics, biochemistry and cell biology; expertise with inducible pluripotent stem cell models for 2D and 3D cultures; previous experience with CRISPR/Cas9 gene editing desirable; excellent team-working and interpersonal skills; enthusiasm and great commitment to research; excellent command of the English language; We offer; exciting international and interdisciplinary research environment; travel opportunities to national and international meetings as well as participation in specialized trainings; an excellent international network in the area of neurodegenerative research; the University of Luxembourg offers highly competitive salaries based on the candidate's experience and is an equal opportunity employer
   
Text: UOL03642 31-Dec-2099 About the University The University of Luxembourg aspires to be one of Europe’s most highly regarded universities with a distinctly international and interdisciplinary character . It fosters the cross-fertilisation of research and teaching , is relevant to its country, is known worldwide for its research and teaching in targeted areas, and is establishing itself as an innovative model for contemporary European Higher Education. It`s core asset is its well-connected world-class academic staff which will attract the most motivated, talented and creative students and young researchers who will learn to enjoy taking up challenges and develop into visionary thinkers able to shape society. Within the University, the Luxembourg Centre for Systems Biomedicine (LCSB) is a highly interdisciplinary research centre (IC), integrating experimental biology and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalized medicine. Your Role The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval. The Translational Neuroscience Group, led by Prof Rejko Krueger, creates a translational bridge between fundamental and the clinic with a focuse on Parkinson’s disease research, with the aim to improve diagnosis and therapy to help patients in Luxembourg and beyond. We are currently looking for an energetic, highly motivated post-doctoral researcher for a collaborative fundamental biology research project in Parkinson’s Disease (PD). Tasks / Activities The post-doctoral researcher will contribute to relevant projects of the Translational Neuroscience Group, in particular to the investigation of the role of different models of α-syn pathogenicity in PD The aim of this project is to characterize patient-based cellular models, e.g. using induced pluripotent stem cells to gain essential knowledge with respect to the molecular mechanisms involved in the pathogenesis of PD. These models then will be explored for serving as cellular readouts for genetic and pharmacological modifications to revert disease associated phenotypes and to disentangle functional networks related to neurodegeneration. Specific tasks can include: conduct research processes to achieve the goals of the project in an interdisciplinary team approach develop methodologies and integrate new technologies collect, assemble and evaluate research data analyses and interpretation of results obtained writing scientific publications and grant applications contribution to research reports perform advanced molecular and cellular biological experiments such as cloning, gene-editing (CrisPR), qPCR generation of viral expression constructs and transduction of patient based cellular models perform various biochemical assays and protein purifications culture of induced pluripotent stem cells (iPSC) into different CNS-related cell types including 3D cultures (organoids) development and application of functional readouts for different mitochondrial and neuronal phenotypes presenting the results at national and international scientific meetings as posters or talks Your Profile PhD in Cellular Biology, Neuroscience, or related discipline strong interest in interdisciplinary research and cellular models of neurodegeneration experience in research and laboratory work profound knowledge of molecular genetics, biochemistry and cell biology expertise with inducible pluripotent stem cell models for 2D and 3D cultures previous experience with CRISPR/Cas9 gene editing desirable excellent team-working and interpersonal skills enthusiasm and great commitment to research excellent command of the English language We offer exciting international and interdisciplinary research environment travel opportunities to national and international meetings as well as participation in specialized trainings an excellent international network in the area of neurodegenerative research the University of Luxembourg offers highly competitive salaries based on the candidate's experience and is an equal opportunity employer In Short Contract Type: 12 months fixed-term contract Work Hours: Full Time 40.0 Hours per Week Starting date: as soon as possible Location: Belval Job Reference: UOL03642 Further Information Applications (in English) should contain the following documents: detailed Curriculum Vitae including a list of publications cover letter mentioning the reference number description of past research experience and future interests Early application is highly encouraged, as the applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by email will not be considered. The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. Here’s what awaits you at the University Multilingual and international character . Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR). A modern and dynamic university. High-quality equipment. WiFi on campus. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure. A partner for society and industry . Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs … Find out more about the University Addresses, maps & routes to the various sites of the University Further information Please contact Prof. Rejko Krüger for further information: rejko.krueger@uni.lu
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