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Position: Research Fellow
Institution: University College London
Department: Division of Biosciences - UCL Institute of Healthy Ageing, Research Department of Genetics, Evolution and Environment
Location: London, United Kingdom
Duties: The project’s aim is to uncover the molecular mechanisms of neuronal cell death in neurodegeneration by modelling the toxicity linked to CCCCGG hexanucleotide repeat expansion (C9), the most common genetic cause of sporadic and familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The candidate will join an exciting research environment integrating fly research with mouse work. The post-holder will be primarily based in Dr Teresa Niccoli’s laboratory but will be working in close collaboration with Dr Adrian Isaacs at the Dementia Research Institute (DRI)
Requirements: PhD in a relevant experimental subject area is desirable, however candidates with a PhD in computational biology will also be considered. Candidates who are independent and highly motivated, but willing and able to work effectively as part of a collaborative team are encouraged to apply
   
Text: Research Fellow, - Ref:1872577 Click here to go back to search results Apply Now UCL Department / Division Division of Biosciences Specific unit / Sub department UCL Institute of Healthy Ageing, Research Department of Genetics, Evolution and Environment Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £36,028 - £43,533 per annum Duties and Responsibilities Applications are invited for a Research Fellow to join the Institute of Healthy Ageing (IHA), in the Department of Genetics, Evolution and Environment, in the laboratory of Dr Teresa Niccoli. The projects aim is to uncover the molecular mechanisms of neuronal cell death in neurodegeneration by modelling the toxicity linked to CCCCGG hexanucleotide repeat expansion (C9), the most common genetic cause of sporadic and familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The candidate will join an exciting research environment integrating fly research with mouse work. The post-holder will be primarily based in Dr Teresa Niccolis laboratory but will be working in close collaboration with Dr Adrian Isaacs at the Dementia Research Institute (DRI). In particular, the post-holder will carry out a large scale single cell sequencing analysis of Drosophila brains expressing C9 repeats, in collaboration with Dr Frigerio at the DRI, to identify potential drivers of C9 toxicity and then carry out an in-depth genetic and molecular analysis, first in flies then in mice. Duration of the post is funded for 3 years in the first instance by an MRC grant. Key Requirements PhD in a relevant experimental subject area is desirable, however candidates with a PhD in computational biology will also be considered. Candidates who are independent and highly motivated, but willing and able to work effectively as part of a collaborative team are encouraged to apply. Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (Salary £31,542 - £33,257 per annum, including London Allowance) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections). Further Details Further particulars, including a job description and person specification, can be accessed at the bottom of this page. Please ensure you read these carefully before applying for the post. To apply for the vacancy please click on the 'Apply Now' button below. For informal enquiries about the post please contact Dr Teresa Niccoli at t.niccoli@ucl.ac.uk. If you have any queries regarding the application process please contact Biosciences staffing on biosciences.staffing@ucl.ac.uk quoting the vacancy reference number: 1872577. UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 9 Nov 2020 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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