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Position: Research Assistant
Institution: University College London
Department: UCL Queen Square Institute of Neurology - Department of Clinical and Movement Neurosciences
Location: London, United Kingdom
Duties: The appointee will develop a range of laboratory skills and work within a dynamic research group. The principal activity will be to perform fluorescent in situ hybridisation (FISH) for SNCA CNVs, combined with immunohistochemistry (IHC) for alpha-synuclein and cell markers in human post mortem sections from the Queen Square Brain Bank (QSBB), analyse all data, and prepare a manuscript for publication. The post holder will also be supported by Dr Zane Jaunmuktane, Neuropathologist at QSBB. There will be the opportunity to further develop lab and analysis techniques relevant to the project. The Proukakis lab has already pioneered the development of SNCA FISH in human brain, single cell whole genome sequencing combined with IHC in MSA, and Nanopore sequencing for GBA
Requirements: The successful candidate must have a BSc or equivalent in neuroscience, genetics or related topic. Applicants will have a strong understanding of biology and genetics of neurodegeneration, especially synucleinopathies, and laboratory experience in genetics, cell biology, neuropathology or closely related topic areas. Experience with statistics and/or data analysis and excellent oral and written communication skills are essential. Advanced computing skills eg ImageJ or equivalent software, R, and an MSc or MRes level in neuroscience, genetics, neuropathology or related topic are desirable
   
Text: Research Assistant, - Ref:1869901 Click here to go back to search results Apply Now UCL Department / Division UCL Queen Square Institute of Neurology Specific unit / Sub department Department of Clinical and Movement Neurosciences Location of position London Grade 6 Hours Full Time Salary (inclusive of London allowance) £31,479 per annum Duties and Responsibilities Applications are invited for a Research Assistant to join the Department of Clinical and Movement Neurosciences to further investigate the role of somatic copy number variants (CNVs) of alpha-synuclein (SNCA) in multiple system atrophy (MSA), funded by the MSA Trust https://www.msatrust.org.uk/blog/2020-research-grant-blog-series-part-3/. The post holder will help further determine whether SNCA somatic CNVs have a direct role in MSA aetiology and pathogenesis, building on previous work recently published by the Proukakis lab. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0873-5 The appointee will develop a range of laboratory skills and work within a dynamic research group. The principal activity will be to perform fluorescent in situ hybridisation (FISH) for SNCA CNVs, combined with immunohistochemistry (IHC) for alpha-synuclein and cell markers in human post mortem sections from the Queen Square Brain Bank (QSBB), analyse all data, and prepare a manuscript for publication. The post holder will also be supported by Dr Zane Jaunmuktane, Neuropathologist at QSBB. There will be the opportunity to further develop lab and analysis techniques relevant to the project. The Proukakis lab has already pioneered the development of SNCA FISH in human brain, single cell whole genome sequencing combined with IHC in MSA, and Nanopore sequencing for GBA. The post is available from October 2020 and is funded by a grant from the MSA Trust for one year in the first instance. Key Requirements The successful candidate must have a BSc or equivalent in neuroscience, genetics or related topic. Applicants will have a strong understanding of biology and genetics of neurodegeneration, especially synucleinopathies, and laboratory experience in genetics, cell biology, neuropathology or closely related topic areas. Experience with statistics and/or data analysis and excellent oral and written communication skills are essential. Advanced computing skills eg ImageJ or equivalent software, R, and an MSc or MRes level in neuroscience, genetics, neuropathology or related topic are desirable. Further Details A Job Description and Person Specification can be accessed at the bottom of this page. To apply for the vacancy, please click on the 'Apply Now' button below. If you have any queries regarding the application process, please contact Oksana Shapoval, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk). Informal inquiries to Dr C Proukakis are strongly encouraged c.proukakis@ucl.ac.uk UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 24 Aug 2020 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. Any offer of employment will be subject to a Disclosure and Barring Service (DBS) check. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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