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Position: Research Fellow
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: This post is based in the Genetics and Genomic Medicine Programme at the UCL Great Ormond Street Institute of Child Health London and is funded by an MRC grant. The aim of the project is to generate data for a natural history study in patients with Ornithine Transcarbamylase Deficiency (OTCD) including work on ureagenesis assays in OTC patients. OTCD is a urea cycle defect causing hyperammonaemia and related intoxication. The patients lacking functional urea cycle are not able to normally metabolise protein catabolism products and therefore need to be fed with a specialist protein restriction diet and are treated with ammonia scavenger drugs. Despite these measures the patients still have recurrent episodes of metabolic decompensation, encephalopathy and liver disease. The work is based on the collaboration between UK clinical metabolic centres
Requirements: The postholder will have a postgraduate degree in biomedical science or equivalent. The postholder will have some experience of writing research ethics proposals, handling patient samples. The postholder will good understanding of the urea cycle, hands on performance of the assay and ureagenesis assay analysis
   
Text: Research Fellow, - Ref:1869978 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,965 - £38,993 per annum Duties and Responsibilities This post is based in the Genetics and Genomic Medicine Programme at the UCL Great Ormond Street Institute of Child Health London and is funded by an MRC grant. The aim of the project is to generate data for a natural history study in patients with Ornithine Transcarbamylase Deficiency (OTCD) including work on ureagenesis assays in OTC patients. OTCD is a urea cycle defect causing hyperammonaemia and related intoxication. The patients lacking functional urea cycle are not able to normally metabolise protein catabolism products and therefore need to be fed with a specialist protein restriction diet and are treated with ammonia scavenger drugs. Despite these measures the patients still have recurrent episodes of metabolic decompensation, encephalopathy and liver disease. The work is based on the collaboration between UK clinical metabolic centres. This post is available for 24 months in the first instance. Key Requirements The post holder will play a crucial role in developing the OTC natural history study and therefore, advanced knowledge and experience in OTCD and clinical research is essential. The post holder will work alongside paediatric metabolic clinical team at GOSH and the UCL team developing the gene therapy trial in OTCD. The post holder will also work collaboratively with other UK clinical metabolic teams. The postholder will have a postgraduate degree in biomedical science or equivalent. The postholder will have some experience of writing research ethics proposals, handling patient samples. The postholder will good understanding of the urea cycle, hands on performance of the assay and ureagenesis assay analysis. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference. UCL Taking Action for Equality Closing Date 27 Aug 2020 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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