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Position: Research Fellow in Leukaemia Stem Cell Biology & Single Cell Genomics
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: The post holder will have the opportunity to interact with a lively community of researchers involved in single-cell genomics studies at ICH and will closely interact with the team of Dr Sergi Castellano, Head of the Genome Biology and Precision Medicine section. Moreover, at ICH, we are ideally placed at the intersection of basic research and clinical translation. The selected post-doc will have the unique opportunity to closely interact with the group of Prof Persis Amrolia, Head of the Section of Molecular and Cellular Immunology and leader in the field of CAR T-cell therapy of haematological malignancies
Requirements: We are seeking a creative researcher with prime interest in stem cell biology, cancer and single cell genomics. Candidates should have a PhD in Molecular/Cellular Biology or equivalent. Extensive experience in multi-colour FACS, haematopoietic stem cell assays, molecular biology (qRT-PCR, RNA-seq) are essential. Experience in single cell biology (mass cytometry and transcriptomic) are highly desirable. Experience in computational analyses of single cell genomic datasets would be an asset
   
Text: Research Fellow in Leukaemia Stem Cell Biology & Single Cell Genomics, - Ref:1860908 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,965 - £38,993 per annum Duties and Responsibilities We are seeking an enthusiastic and highly motivated post-doctoral researcher to join the research group of Dr Alice Giustacchini at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology. Molecular and cytotoxic therapies in cancer can often induce remission without achieving a complete disease eradication, potentially resulting in relapse and poor prognosis. A better understanding of cell-to-cell heterogeneity in cancer is crucial for the development of effective therapeutic strategies accounting for the complexity of the disease. We have previously shown that Myeloid Leukaemia stem cells display a high degree of heterogeneity, with cells carrying a distinct transcriptomic signature of therapy-resistance being identified already at diagnosis and progressively enriched with treatment1. With this project, combining state of the art single-cell genomics and proteomic measurements with stem cell functional assays, we aim at the identification and characterization of leukaemia stem cells responsible for treatment escape and disease relapse. The post holder will have the opportunity to interact with a lively community of researchers involved in single-cell genomics studies at ICH and will closely interact with the team of Dr Sergi Castellano, Head of the Genome Biology and Precision Medicine section. Moreover, at ICH, we are ideally placed at the intersection of basic research and clinical translation. The selected post-doc will have the unique opportunity to closely interact with the group of Prof Persis Amrolia, Head of the Section of Molecular and Cellular Immunology and leader in the field of CAR T-cell therapy of haematological malignancies. The project is funded by Cancer Research UK (CRUK) for 2 years or until 30/04/2022 in the first instance. Key Requirements We are seeking a creative researcher with prime interest in stem cell biology, cancer and single cell genomics. Candidates should have a PhD in Molecular/Cellular Biology or equivalent. Extensive experience in multi-colour FACS, haematopoietic stem cell assays, molecular biology (qRT-PCR, RNA-seq) are essential. Experience in single cell biology (mass cytometry and transcriptomic) are highly desirable. Experience in computational analyses of single cell genomic datasets would be an asset. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference 1860908. UCL Taking Action for Equality Closing Date 3 Apr 2020 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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