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Position: Research Fellow
Institution: University College London
Department: UCL Queen Square Institute of Neurology - Department of Clinical and Movement Neurosciences
Location: London, United Kingdom
Duties: Applications are invited for a Research Fellow in the Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology under the supervision of Dr Sonia Gandhi. The project harnesses the power of iPS technology to generate region specific highly enriched neuronal and astrocytic cultures, and to utilise them to model the effect of PD causing mutations on cellular function. Conceptually, the project focuses on key processes or protein aggregation, mitochondrial dysfunction, and inflammation in familial forms of Parkinsons disease to understand how these processes lead to neuronal death
Requirements: Applicants should have a PhD in Neuroscience/Cell Biology and experience with iPSCs and directed differentiation. The ability to work in a diverse group including computational and experimental neurobiologists is essential, as is the ability to organise work and prioritise work, and to write clearly and succinctly for publication. The ability to present research findings with authority and coherence to a variety of audiences at national and international conferences, seminars and project meetings is also a requirement. Experience analysing RNAseq data and of molecular biology techniques, including gene editing is desirable; If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start date
   
Text: Research Fellow, - Ref:1860126 Click here to go back to search results Apply Now UCL Department / Division UCL Queen Square Institute of Neurology Specific unit / Sub department Department of Clinical and Movement Neurosciences Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,965 per annum Duties and Responsibilities Applications are invited for a Research Fellow in the Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology under the supervision of Dr Sonia Gandhi. The project harnesses the power of iPS technology to generate region specific highly enriched neuronal and astrocytic cultures, and to utilise them to model the effect of PD causing mutations on cellular function. Conceptually, the project focuses on key processes or protein aggregation, mitochondrial dysfunction, and inflammation in familial forms of Parkinsons disease to understand how these processes lead to neuronal death. The post is based at the Francis Crick Institute and UCL Queen Square Institute of Neurology, in the laboratory of Dr Sonia Gandhi. The post holder will use a range of single cell, single molecule and super resolution imaging approaches to study these pathways in iPS derived neurons and astrocytes. Imaging analyses will be integrated with transcriptomic and metabolomic analyses. Manipulation of key pathways using CRISPR-based approaches will be performed in the iPS system. Testing of key hypotheses in human post-mortem brain will be an integral component to the project. The post is available immediately and is funded by a grant from the MRC for two years in the first instance. Key Requirements Applicants should have a PhD in Neuroscience / Cell Biology and experience with iPSCs and directed differentiation. The ability to work in a diverse group including computational and experimental neurobiologists is essential, as is the ability to organise work and prioritise work, and to write clearly and succinctly for publication. The ability to present research findings with authority and coherence to a variety of audiences at national and international conferences, seminars and project meetings is also a requirement. Experience analysing RNAseq data and of molecular biology techniques, including gene editing is desirable. If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start date. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,479 - £33,194 pa) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis Further Details To apply for the vacancy, please click on the 'Apply Now' button below. A full job description is accessible below. If you have any queries regarding the application process, please contact Samantha Robinson, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk ). UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 3 Mar 2020 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description Apply Now
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