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Position: PhD position Bioinspired Hybrid Functional Compartments: Towards "Artificial Cellular Implants&#034
Institution: Universität Basel
Location: Basel, Switzerland
Duties: The PhD project has as aim the design and development of hybrid compartments based on a combination of synthetic compartments with active biomolecules such to serve as "artificial cellular implants" for medical applications. Synthetic compartments decorated with single strands DNA will be self-organized in clusters via DNA hybridization and loaded with specific biomolecules to trigger a bio-reply in cells. A particularly important part of the project will intend to decorate the clusters with different DNA strands and evaluate their overall architecture. The wall of the compartments will be rendered permeable by insertion of synthetic pores, while their external surface will expose specific molecular groups for targeting of the cells
Requirements: you have an MS degree in chemistry, biochemistry or material science; knowledge of physical chemistry methods (e.g. IR and electronic spectroscopy, fluorescence spectroscopy, NMR, Fluorescence correlation spectroscopy, light/neutron scattering); experience with enzymatic kinetics and cells assays desirable; citizenship of Switzerland or one EU country; proficiency in English, and preferably German; great social and communication skills for integration into an international research team
   
Text: Universität Basel: PhD position PhD position Bioinspired Hybrid Functional Compartments: Towards "Artificial Cellular Implants" Candidates are invited to apply for a PhD position in the Department of Chemistry of the University of Basel. Your position The PhD project has as aim the design and development of hybrid compartments based on a combination of synthetic compartments with active biomolecules such to serve as "artificial cellular implants" for medical applications. Synthetic compartments decorated with single strands DNA will be self-organized in clusters via DNA hybridization and loaded with specific biomolecules to trigger a bio-reply in cells. A particularly important part of the project will intend to decorate the clusters with different DNA strands and evaluate their overall architecture. The wall of the compartments will be rendered permeable by insertion of synthetic pores, while their external surface will expose specific molecular groups for targeting of the cells. The PhD is interdisciplinary and will combine nanoscience with physical chemistry and biochemistry methods to generate and characterize such compartments equipped with active molecules. These hybrid compartments will be tested in vitro in terms of functionality as an essential step for the development of "synthetic cellular implants". For more information on the topics of the group with which you will work, see: http://www.chemie1.unibas.ch/~palivan/ or at https://chemie.unibas.ch/de/forschung/nanomaterialien/ Your profile you have an MS degree in chemistry, biochemistry or material science. knowledge of physical chemistry methods (e.g. IR and electronic spectroscopy, fluorescence spectroscopy, NMR, Fluorescence correlation spectroscopy, light/neutron scattering) experience with enzymatic kinetics and cells assays desirable citizenship of Switzerland or one EU country proficiency in English, and preferably German great social and communication skills for integration into an international research team Application / Contact For further information please contact Prof. Dr. Cornelia Palivan, (Cornelia.Palivan@unibas.ch, phone: 41.61.2073839). Interested candidates will send, by 10.03.2020: i. letter of motivation, ii. curriculum vitae, and iii. names and contact details for two referees. The University of Basel is an Equal Opportunity Employer www.unibas.ch
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