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Position: Research Fellow in single cell genomics
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: The study involves performing single cell experiments from tissues prospectively collected from the placenta and placental bed, via biopsy at time of delivery when a pregnancy complication (fetal growth restriction, pre-eclampsia and preterm birth) has been recognised, as well as the analysis of fetal cells retrieved from the maternal circulation. We will analyse the tissue and cells obtained through both spatial and single cell transcriptomics and genomics to build an accurate representation of cell populations at the maternal-fetal interface. This will allow us to dissect maternal and fetal cell populations, their individual roles at the maternal-fetal interface (e.g. migration properties), as well as the communication between them. This project is a collaboration with Dr Sara Hillman, an expert in maternal and fetal medicine, who will be collecting the placental samples and overseeing the collection of maternal blood and pregnancy and outcome data, but will also benefit from additional expertise at the UCL GOS Institute of Child Health and the London North Genomic Laboratory Hub based at Great Ormond Street Hospital
Requirements: We are seeking to appoint a creative and highly motivated researcher with prime interest in performing single cell experiments. Candidates should have an experimental PhD in related genomic disciplines. The ideal candidate will have experience in single cell genomics, a strong interest in spatial transcriptomics, and some experience in single cell data analysis. Previous experimental work in translational medicine is a plus. Experience with large-scale genomic datasets, functional genomics and next-generation sequencing data are also an advantage. The successful candidate will have the opportunity to contribute to other single cell projects in maternal and fetal medicine and other areas of maternal child health
   
Text: Research Fellow in single cell genomics, - Ref:1857742 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,965 - £40,062 per annum Duties and Responsibilities Undertake research under supervision within a specific research project and as a member of a research team. Develop and plan an area of personal research and expertise. This study is designed to investigate pathologies associated with the placental interface of maternal and fetal cells. Dysfunction in the placenta is believed to drive many common obstetric complications (such as pre-eclampsia and fetal growth restriction) that affect women. The close approximation in the placenta of maternal and fetal cells makes it an invaluable organ to better understand human pregnancy, as well as its complications. Further, with the growing area of non-invasive prenatal diagnosis, a key area at of research at the Great Ormond Street NHS Foundation Trust, we will explore the use of single cells in the maternal circulation. A better characterisation of the behaviour and genomic constitution of fetal cells will contribute to improved understanding and diagnosis of fetal complications. The study involves performing single cell experiments from tissues prospectively collected from the placenta and placental bed, via biopsy at time of delivery when a pregnancy complication (fetal growth restriction, pre-eclampsia and preterm birth) has been recognised, as well as the analysis of fetal cells retrieved from the maternal circulation. We will analyse the tissue and cells obtained through both spatial and single cell transcriptomics and genomics to build an accurate representation of cell populations at the maternal-fetal interface. This will allow us to dissect maternal and fetal cell populations, their individual roles at the maternal-fetal interface (e.g. migration properties), as well as the communication between them. This project is a collaboration with Dr Sara Hillman, an expert in maternal and fetal medicine, who will be collecting the placental samples and overseeing the collection of maternal blood and pregnancy and outcome data, but will also benefit from additional expertise at the UCL GOS Institute of Child Health and the London North Genomic Laboratory Hub based at Great Ormond Street Hospital. The post holder will be expected to undertake research under supervision within a specific research project and as a member of a research team and Develop and plan an area of personal research and expertise. This position is available until 31 March 2022 or 2 years in the first instance. Key Requirements We are seeking to appoint a creative and highly motivated researcher with prime interest in performing single cell experiments. Candidates should have an experimental PhD in related genomic disciplines. The ideal candidate will have experience in single cell genomics, a strong interest in spatial transcriptomics, and some experience in single cell data analysis. Previous experimental work in translational medicine is a plus. Experience with large-scale genomic datasets, functional genomics and next-generation sequencing data are also an advantage. The successful candidate will have the opportunity to contribute to other single cell projects in maternal and fetal medicine and other areas of maternal child health. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. Informal inquires can be sent to Sergi Castellano, s.castellano@ucl.ac.uk , Sara Hillman, sara.hillman@ucl.ac.uk and Lyn Chitty, l.chitty@ucl.ac.uk . If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference UCL Taking Action for Equality Closing Date 14 Feb 2020 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job description Apply Now
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