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Position: Research Fellow
Institution: University College London
Department: Great Ormond Street Institute of Child Health
Location: London, United Kingdom
Duties: The main duties of the post are: Perform experiments to determine if de novo dystrophin resulting from skipping of exon 53 induced in patient derived fibroblasts results in the expected size shift of dystrophin protein and Perform experiments to determine if there are differences in dystrophin transcript stability resulting from different patient mutations and/or exon skipping efficiency in patient derived fibroblasts
Requirements: Applicants must have a PhD in a relevant subject. The successful applicant will have experience of molecular biology techniques, including qPCR, RT-PCR, cell culture, including culture and transfection of primary cells, immunohisto chemical techniques, Western blotting and digital image analysis
   
Text: Research Fellow, - Ref:1857748 Click here to go back to search results Apply Now UCL Department / Division Great Ormond Street Institute of Child Health Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,965 - £43,470 per annum Duties and Responsibilities Applications are invited for a Research Fellow to join a well funded, highly interactive research group led by Professor Francesco Muntoni which is investigating the molecular basis of, and treatment for, Neuromuscular diseases. You will be involved in a project which aims to analyse exploratory biomarkers in patients that have participated in a clinical trial aimed at restoring dystrophin production in a subset of Duchenne muscular dystrophy (DMD) patients, by a drug that skips the mutations causing DMD. The main duties of the post are: Perform experiments to determine if de novo dystrophin resulting from skipping of exon 53 induced in patient derived fibroblasts results in the expected size shift of dystrophin protein and Perform experiments to determine if there are differences in dystrophin transcript stability resulting from different patient mutations and/or exon skipping efficiency in patient derived fibroblasts. This post is available for 3 months from 23 February 2020 until 26 May 2020. Key Requirements Applicants must have a PhD in a relevant subject. The successful applicant will have experience of molecular biology techniques, including qPCR, RT-PCR, cell culture, including culture and transfection of primary cells, immunohisto chemical techniques, Western blotting and digital image analysis. Further Details A job description and person specification can be accessed at the bottom of the page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference. UCL Taking Action for Equality Closing Date 28 Jan 2020 Latest time for the submission of applications 23.59 Interview date TBC This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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