Visit www.acad.jobs with all Jobs for Academics!
                    
Position: Research Fellow in Applied Molecular Biology/Haematology for Gene Delivey and T-Cell Bioprocessing Applications
Institution: University College London
Department: Biochemical Engineering
Location: London, United Kingdom
Duties: We are seeking to recruit a proactive, collaborative, dedicated, well organised, highly motivated, and driven Postdoctoral Research Fellow to join the Advanced Therapy Bioprocessing Group and lead the T-cell immunotherapy development, with a specific focus on gene delivery. The PDRA, under the supervision of Dr Qasim Rafiq, will be responsible for developing gene delivery platforms for T-cell immunotherapy applications and identifying novel and innovative ways of redefining these processes for a personalised manufacturing paradigm. This will include understanding the biology of viral vectors, human immunology as well as simplifying and optimising the isolation of T-cells in addition to their upstream/downstream processing, characterisation and cell analysis
Requirements: A PhD awarded (or about to be) in a relevant subject. This may include biological sciences, cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to gene delivery for T-cell applications, and an interest in developing an understanding of how to control T-cell fate in novel platform technologies; Experience with plasmid and virus production, including experience of working with HEK cells for lentiviral production; Training and experience in working with primary T-cells, including their isolation, expansion and analysis; Experience with cell characterisation assays including flow cytometry, ELISA, qPCR and other relevant assays for T-cell culture; Experience in the study of microRNAs and their manipulation; Ability to use creative problem-solving skills to independently design experiments and troubleshoot experimental challenges; Able to perform studies accurately and reproducibly, accomplish project objectives, and meet or exceed expectations while effectively contributing to the team; You should have genuine passion and commitment for the development of innovative solutions to T-cell immunotherapies; Be positively-minded and solution focused
   
Text: Research Fellow in Applied Molecular Biology/Haematology for Gene Delivey and T-Cell Bioprocessing Applications, - Ref:1816864 Click here to go back to search results Apply Now UCL Department / Division Biochemical Engineering Location of position London Grade 7 Hours Full Time (Job share considered) Salary (inclusive of London allowance) £35,328 - £42,701 per annum Duties and Responsibilities The EPSRC-funded Future Targeted Healthcare Manufacturing Hub is an international programme hosted by the Advanced Centre for Biochemical Engineering (ACBE) at UCL with funding from the EPSRC and a user consortium. The Hub has collaborative Spokes at Imperial College London and the Universities of Loughborough, Manchester, Nottingham and Warwick. The Hub network of international companies and universities brings together process engineers, life scientists, pharmacists, mechanical engineers, public policy scientists and health economists. The Hub focuses on research questions focusing on creating innovative manufacturing and formulation routes, analytical and process control methods, and associated computational decision-support frameworks, to revolutionise the delivery of cost-effective stratified protein-based and personalised cell-based therapies to patients. We are seeking to recruit a proactive, collaborative, dedicated, well organised, highly motivated, and driven Postdoctoral Research Fellow to join the Advanced Therapy Bioprocessing Group and lead the T-cell immunotherapy development, with a specific focus on gene delivery. The PDRA, under the supervision of Dr Qasim Rafiq, will be responsible for developing gene delivery platforms for T-cell immunotherapy applications and identifying novel and innovative ways of redefining these processes for a personalised manufacturing paradigm. This will include understanding the biology of viral vectors, human immunology as well as simplifying and optimising the isolation of T-cells in addition to their upstream/downstream processing, characterisation and cell analysis. While the Hub is funded for seven years in total, the position will be offered for two years in the fist instance and extended as required on a yearly basis. The post is available from 1 October 2019. As the UCL Hub Postdoctoral Research Fellow you will: Devise and undertake appropriate experiments to achieve the goals and milestones as described in the research programme, submitted to the sponsor. This would include a significant element of independent work, e.g. in the planning and execution of experiments, and the write up of work for publication. Interact with the researchers, PDRAs and investigators within the Advanced Therapy Bioprocessing Group at UCL and all personnel involved in the Hub at the partner universities to successfully deliver the project. Write regular reports to the supervisor, compile data acquired in a form to allow rapid transformation of documented research results into high quality research papers and/or patent applications, communicate the results during regular meetings. Maintain an up to date/detailed log of the research activity undertaken and of the results obtained. Key Requirements To succeed in this role you will have: A PhD awarded (or about to be) in a relevant subject. This may include biological sciences, cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to gene delivery for T-cell applications, and an interest in developing an understanding of how to control T-cell fate in novel platform technologies. Experience with plasmid and virus production, including experience of working with HEK cells for lentiviral production. Training and experience in working with primary T-cells, including their isolation, expansion and analysis. Experience with cell characterisation assays including flow cytometry, ELISA, qPCR and other relevant assays for T-cell culture. Experience in the study of microRNAs and their manipulation Ability to use creative problem-solving skills to independently design experiments and troubleshoot experimental challenges. Able to perform studies accurately and reproducibly, accomplish project objectives, and meet or exceed expectations while effectively contributing to the team. You should have genuine passion and commitment for the development of innovative solutions to T-cell immunotherapies. Be positively-minded and solution focused. The Advanced Therapy Bioprocessing Group within the UCL Department of Biochemical Engineering focuses on addressing research challenges associated with the translation, manufacture and delivery of regenerative medicines and cell and gene therapies. Our core research is focus on expediting and accelerating the development, commercialisation and adoption of these therapies with the aim of making advanced therapies widely accessible. We believe that the translational and manufacturing challenges need to be addressed in order to make these therapies cost effective and are driven by this goal. RoosterBio is a revenue stage company on a high growth trajectory. Our group members, including research students, research associates and investigators are collectively driven by high impact work and are passionate about delivering the high quality research that will deliver solutions to current problems. We do not compromise on our goal to establish a high performing, innovative and collaborative team environment and we believe in recruiting and developing the best researchers available within the field. We set ourselves high standards, ensure that the work we do keeps up with the fast pace across industry and academia, and we support each other to ensure we get the best out of each team member and the group as a whole. Further Details A job description and person specification can be accessed below. To apply for the vacancy, please click on the Apply Now button. If you have any queries regarding the application process, please contact Qasim Rafiq, q.rafiq@ucl.ac.uk We particularly welcome applications from black and minority ethnic candidates as they are under-represented within UCL at this level. Closing Date 17 Jul 2019 Latest time for the submission of applications 23.59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description Apply Now
Please click here, if the Job didn't load correctly.







Please wait. You are being redirected to the Job in 3 seconds.