This studentship will aim to provide mechanistic insight into local signals that regulate microglia-synapse pruning to aid foundational knowledge of brain physiology
Applicants who have or expect to obtain a 1st or upper 2nd class honours degree in biochemistry, molecular biology, neuroscience, biomedical sciences or related disciplines
PhD Studentship - Immune basis of neurologic function and circuitry, - Ref:1812404 Click here to go back to search results UCL Department / Division UCL Queen Square Institute of Neurology Specific unit / Sub department Dementia Research Institute (DRI) @ UCL Location of position London Stipend £21,009 per annum Vacancy Information Applications are invited for a fully-funded PhD studentship in the UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, to start 1st October 2019. Project: Microglia are active participants in brain wiring sculpting and refining neural circuits and influencing synaptic development and function. Microglia mediate synapse pruning via complement signalling (C1q, CR3/C3) in the developing brain (Stevens et al., Cell 2007, Schafer et al., Neuron 2012) and when this process is reactivated in the adult brain, synapses are lost (Hong et al., Science, 2016, Lui et al. Cell 2016, Vasek et al., Nature 2016, Dejavonic et al., Neuron 2018, Shi et al., Science Translational Medicine 2017). Complement components are induced during normal ageing (Stephan et al., J. Neurosci. 2013) but the molecular mechanisms that govern how and which synapses are targeted are poorly understood. Understanding what regulates complement signalling in the adult brain is crucial to learning how microglia and neurons communicate with each other to maintain proper brain function. This studentship will aim to provide mechanistic insight into local signals that regulate microglia-synapse pruning to aid foundational knowledge of brain physiology. Studentship Description Funding: The studentship is funded through a BBSRC Collaborative Training Partnership CASE award with AstraZeneca for 4 years and will cover UK/EU university tuition fees and an annual stipend of £21,009. Entry requirements: Applicants who have or expect to obtain a 1st or upper 2nd class honours degree in biochemistry, molecular biology, neuroscience, biomedical sciences or related disciplines. Eligibility: In line with BBSRC eligibility conditions, the studentship is open to UK and EU candidates. EU candidates must have been living in the UK for 3 years prior to the course commencing. Informal enquiries: Please email Dr Soyon Hong for further information about the project ( email@example.com ) Application procedures: Application is by CV and covering letter emailed to firstname.lastname@example.org . The successful applicant will then need to apply online to UCL by submitting the PhD application form via https://www.ucl.ac.uk/prospective-students/graduate/apply Contact name Oksana Shapoval Contact details email@example.com UCL Taking Action for Equality Closing Date 5 Jul 2019 Latest time for the submission of applications 5pm Interview date TBC This role does not meet the eligibility requirements for a tier 2 certificate of sponsorship under UK Visas and Immigration legislation. Therefore UCL will not be able to sponsor individuals who require right to work in the UK to carry out this role.
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