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Position: Research Fellow
Institution: University College London
Department: EGA Institute for Womens Health - Maternal & Fetal Medicine
Location: London, United Kingdom
Duties: Applicants are invited for a Research Fellow position in an exciting research programme held at the newly built Zayed Centre for Research into Rare Disease in Children, on developing innovative treatments for the brittle bone disease osteogenesis imperfect. The aim of the research is to combine cellular reprogramming to pluripotency (iPSCs), CRISPR-Cas9 genome editing, organ-on-chip and model organisms to develop to next generation of stem cell-based (stem cells and exosomes) personalised therapeutics for the treatment of osteogenesis imperfecta
Requirements: Molecular biology, cell biology and genome editing of iPSCs using CRISPR-Cas9 experience is essential, and experience with osteogenic differentiation is an advantage; Applicants must have a higher degree in a relevant discipline (molecular OR cell biology) at PhD level; Previous experience with a productive track record working with iPSCs and mesenchymal stem cells derived from iPSC (iMSC) is strongly recommended, though individuals without iMSC experience, but with an exceptional track record in related areas such as MSC-derived exosomes, are also encouraged to apply
   
Text: Research Fellow, - Ref:1809641 Click here to go back to search results Apply Now UCL Department / Division EGA Institute for Womens Health Specific unit / Sub department Maternal & Fetal Medicine Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) £35,328 per annum Duties and Responsibilities Applicants are invited for a Research Fellow position in an exciting research programme held at the newly built Zayed Centre for Research into Rare Disease in Children, on developing innovative treatments for the brittle bone disease osteogenesis imperfect. The aim of the research is to combine cellular reprogramming to pluripotency (iPSCs), CRISPR-Cas9 genome editing, organ-on-chip and model organisms to develop to next generation of stem cell-based (stem cells and exosomes) personalised therapeutics for the treatment of osteogenesis imperfecta. The successful candidate will contribute to 3 aspects of the research programme: 1. To engineer and develop various stem cell lines and isolated the exosomes they release as new therapeutic products. 2. To test their efficacy to counteract bone fragility in vitro and in vivo. 3. To establish the impact of the OI-causative mutation on osteoblast function to determine the molecular mechanisms underlying OI progression. The post is funded for 3 years in the first instance and is available 1st October 2019. Funding end date is 30th September 2022. Key Requirements Molecular biology, cell biology and genome editing of iPSCs using CRISPR-Cas9 experience is essential, and experience with osteogenic differentiation is an advantage. Applicants must have a higher degree in a relevant discipline (molecular OR cell biology) at PhD level. Previous experience with a productive track record working with iPSCs and mesenchymal stem cells derived from iPSC (iMSC) is strongly recommended, though individuals without iMSC experience, but with an exceptional track record in related areas such as MSC-derived exosomes, are also encouraged to apply. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the Apply Now button below. If you have any queries regarding the vacancy, please contact Dr. Pascale V Guillot, p.guillot@ucl.ac.uk, 44(0)7703 343 449. If you have any queries regarding the application process please contact HR Administrator at IfWH Christina Ahlfors, at 020 3108 2033 or c.ahlfors@ucl.ac.uk. UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 8 Jul 2019 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Gold award, in recognition of our long-term commitment and 'beacon' status in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description Apply Now
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