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Position: Research Fellow
Institution: University College London
Department: Cancer Section - Developmental Biology and Cancer Programme
Location: London, United Kingdom
Duties: Our recent research identifies potent anti-AML activity of mebendazole, through targeting the transcription factor c-MYB for proteasomal degradation. We will take this research to the next stage by examining the anti-leukaemia activity of mebendazole in a number of different AML models, including patient-derived AML xenografts, and its potential synergy with existing and experimental anti-AML therapies. We envisage that this research will form the basis for initiating clinical trials with the aim of translating mebendazole into paediatric AML therapy. You will perform molecular biological, haematopoietic and biochemical experiments using leukaemia cell lines, patient-derived xenograft leukaemia cells and pre-clinical leukaemia models
Requirements: Experience in some or all of the following are essential: leukaemia cell culture, haematopoietic assays, patient-derived xenograft culture, lentiviral transduction, quantitative rt-PCR, routine protein biochemistry and western blot analysis, and flow cytometry. Experience in advanced cell biology and in vivo experimentation is essential. Applicants must have (or at least submitted) a PhD in experimental biology, particularly haematopoietic and leukaemia research, and have a publication record commensurate with research experience in a relevant subject area
   
Text: Research Fellow, - Ref:1804569 Click here to go back to search results Apply Now UCL Department / Division UCL Great Ormond Street Institute of Child Health Specific unit / Sub department Cancer Section - Developmental Biology and Cancer Programme Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) ?35,328 - ?38,303 per annum Duties and Responsibilities Applicants are invited for a Research Fellow within the laboratory of Dr Owen Williams at the UCL Great Ormond Street Institute of Child Health. The overall objective of this project is to generate pre-clinical data that will validate and promote the repositioning of the anti-helminth drug mebendazole into the therapy of paediatric Acute Myeloid Leukaemia (AML). This project is based on our recent research identifying potent anti-AML activity of mebendazole, through targeting the transcription factor c-MYB for proteasomal degradation. The current project will take this research to the next stage by examining the anti-leukaemia activity of mebendazole in a number of different AML models, including patient-derived AML xenografts, and its potential synergy with existing and experimental anti-AML therapies. We envisage that this research will form the basis for initiating clinical trials with the aim of translating mebendazole into paediatric AML therapy. The role of the post holder will be to perform molecular biological, haematopoietic and biochemical experiments using leukaemia cell lines, patient-derived xenograft leukaemia cells and pre-clinical leukaemia models. This post is funded for 3 years in the first instance. Key Requirements Experience in some or all of the following are essential: leukaemia cell culture, haematopoietic assays, patient-derived xenograft culture, lentiviral transduction, quantitative rt-PCR, routine protein biochemistry and western blot analysis, and flow cytometry. Experience in advanced cell biology and in vivo experimentation is essential. Applicants must have (or at least submitted) a PhD in experimental biology, particularly haematopoietic and leukaemia research, and have a publication record commensurate with research experience in a relevant subject area. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the ?Apply Now? button below. If you have any queries regarding the vacancy or the application process, please contact Susan Lloyd, Programme Administrator, Email: ich.dbc.admin@ucl.ac.uk UCL Taking Action for Equality Closing Date 14 Jun 2019 Interview date 24 June 2019 Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description Apply Now
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