The PhD student will use electrophysiological and optical approaches, in particular the voltage-clamp fluorometry technique to study conformational changes of ASICs. The PhD student will also use methods of cell biology and molecular biology
We are looking for a talented and motivated doctoral student. Applicants should hold a Master or equivalent academic degree. Experience in electrophysiology (patch-clamp, two-electrode voltage-clamp), optical methods, molecular biology and cell biology is welcome and will be an advantage, but is not a prerequisite
PhD student positionin ion channel researchA Ph.D. student position is available at the Department of Pharmacologyand Toxicology (DPT)ofthe University of Lausanne to study structure/function aspectsof acid-sensing ion channels (ASICs). ASICs areneuronal ion channelsinvolved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Wemmie JAet al., Nat Rev Neurosci 14: 461-471, 2013; Kellenberger S and Schild L, Pharmacol Rev 67: 1-35, 2015). In our laboratory we aim atunderstandingthe molecular mechanisms by which protons activate the ASIC channels. The PhD student will use electrophysiological and opticalapproaches, in particular the voltage-clamp fluorometry technique (Talwar S and Lynch, JW, Neuropharmacology 98:3-12, 2015) to study conformational changes of ASICs. The PhD student willalsousemethods of cell biology and molecular biology. The DPT, with 10research teams, offers a stimulating and competitive research environment in modern biologywith multidisciplinary expertise (www.unil.ch/dpt).Your profile:We are looking for a talented and motivated doctoral student. Applicants should hold a Master or equivalent academic degree that is acceptable for admissionas a PhDstudent in one of the doctoral schools at the Faculty of Biologyand Medicineof the University of Lausanne(www.unil.ch/ecoledoctoralefbm). Experience in electrophysiology(patch-clamp, two-electrode voltage-clamp),optical methods, molecular biology and cell biology is welcomeand will be an advantage,butisnot a prerequisite. Beginning:July or August2019or upon agreementApplicationsby e-mailare invited in the form of a motivation letter, a curriculum vitae, copies of University exams and degrees, a brief description of laboratory experienceand the master thesis,and the names and addresses of two academic references, before April 28.Please note that incomplete applications will not be considered.Contact addressfor inquiries and for submission of applications:Dr. Stephan KellenbergerPD-MER, Département de Pharmacologie et de Toxicologie, Université de Lausanne, Rue du Bugnon 27, CH-1011Lausanne, tel. ++4121 692 5422, firstname.lastname@example.org, www.unil.ch/dpt/home/menuinst/recherche/groupe-kellenberger.htmlFor further information, please consult the following publications:Bonifacio G et al. (2014) J Gen Physiol 143:105-118Vullo S et al. (2017) Proc Natl Acad Sci USA 114: 3768-3773
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