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Position: Research Fellow
Institution: University of Warwick
Location: Coventry, England, United Kingdom
Duties: You will work on a Cancer Research UK-funded programme to understand protein complexes that crosslink microtubules in the mitotic spindle. You will take a structural-cell biology approach to this problem by analysing the spindle stabilizing complexes using structural methods and applying some cell biology. The Bayliss lab use structural methods (cryoEM, X-ray crystallography, NMR) and biophysical approaches while the Royle lab specialize in quantitative imaging (light and electron microscopy) and gene editing in human cells
Requirements: Good honours degree and possession of a PhD, or close to completion of a PhD in a relevant discipline. Proven ability in research and evidence of quality research output in relevant field at all stages of training. Developing research profile with the ability to publish and/or produce high quality research output. Papers or manuscripts deposited on a preprint server are acceptable. Sufficient breadth and depth of specialist knowledge in the research methods and techniques to relevant structural biology. Experience in at least one: structural analysis, biophysical methods relevant to protein complexes, quantitative cell biology, advanced electron microscopy. Ability and potential to contribute to the development of funding proposals in order to generate external funding to support research projects. Ability to accurately and meticulously record procedures and results (both in notebooks and electronically). Competent in lab calculations
   
Text: Research Fellow (101444-049) Click here to go back to search results Apply Now Vacancy Type/Job category Research Only Department Warwick Medical School, Biomedical Cell Biology Salary ?30,395 - ?39,609 per annum Location University of Warwick, Coventry Vacancy Overview Fixed Term Contract for 2 Years Mitotic spindle stability is important for accurate chromosome segregation. We are characterising protein complexes involved in stabilising the mitotic spindle using structural and cell biological approaches (Nixon et al. 2015 eLife; Burgess et al. 2018 EMBO J). We are interested in studying how these protein complexes assemble and how they attach to microtubules. The goal is to understand how the kinetochore fibres of the spindle are stabilised normally and how this process becomes misregulated in cancer. You will join the laboratories of Stephen Royle in the Centre for Mechanochemical Cell Biology, Warwick Medical School and Richard Bayliss in The Astbury Centre, University of Leeds. We use structural and biophysical methods, biochemistry, imaging (light and electron microscopy), and gene editing to understand the role of protein complexes that stabilise microtubules within the mitotic spindle in human cells. We offer outstanding environments for discovery science in two of the best universities in the UK. You will have a good honours degree and have, or expect shortly to have, a relevant PhD, plus experience in cell biology/biochemistry or structural studies, strong scientific interest and motivation. A strong publication record is preferred. Where you have not yet been awarded your PhD, any offer made to you will be an under-appointment to the post of Research Assistant at a salary of ?29,515 per annum. Once your PhD has been awarded, you will be appointed to the substantive post of Research Fellow at a salary within the range shown above. Job Description Job Purpose You will work on a Cancer Research UK-funded programme to understand protein complexes that crosslink microtubules in the mitotic spindle. Our goal is to understand mitotic spindle stability. In particular, we are interested in ?the mesh? ? a network of proteins that organise microtubules of the kinetochore fibres in the mitotic spindle (Nixon et al., eLife 2015). We are identifying and characterising protein complexes in the mesh (Burgess et al. EMBO J 2018) and discovering how they stabilise microtubules. We want to understand how this works in normal cells and how it goes wrong in cancer. You will take a structural-cell biology approach to this problem by analysing the spindle stabilizing complexes using structural methods and applying some cell biology. The Bayliss lab use structural methods (cryoEM, X-ray crystallography, NMR) and biophysical approaches while the Royle lab specialize in quantitative imaging (light and electron microscopy) and gene editing in human cells. The appointment will be based in the Royle lab in Warwick in collaboration with the Bayliss lab in Leeds. Strong interest in both structural studies and cell biology is essential. Duties and Responsibilities Research and Scholarship 1. Maintain a sound research base within the department in order to assist the development of research objectives and proposals for own or joint research. 2. Conduct individual and collaborative research projects. 3. Meticulous record keeping, accurate conduct and reporting of experimental setup and data. Adherence to lab standards for archiving, analysis and reporting. 4. Write up research work for publication. 5. Translate knowledge of advances in the subject area into research activity. 6. May contribute to preparing proposals and applications to external bodies, e.g. for funding and contractual purposes, to support a developing research agenda. 7. Contribute to the preparation of papers for publication. 8. Communicate complex information (orally and in writing) and material of a specialist or highly technical nature. 9. Continually update own knowledge and understanding in field or specialism. Teaching and Learning Support 1. Opportunities to contribute to the teaching and learning programmes in the department. 2. Assist in the supervision of student projects and the development of student research skills. 3. May be involved in the assessment of student knowledge and supervision of projects. Administration and Other Activities 1. May be required to attend departmental meetings and to participate (where necessary) in other committees and working groups within the department, the faculty and the University. 2. Ensure compliance with health and safety in all aspects of work. 3. Work within budget constraints. The duties and responsibilities outlined are not intended to be an exhaustive list but provide guidance on the main aspects of the job. The post-holder will be required to be flexible in their duties. Person Specification The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. This is measured by (a) Application Form, (b) Test/Exercise, (c) Interview, (d) Presentation. Essential Criteria 1 Good honours degree and possession of a PhD, or close to completion of a PhD in a relevant discipline. (a)(c) Essential Criteria 2 Proven ability in research and evidence of quality research output in relevant field at all stages of training. (a)(c)(d) Essential Criteria 3 A developing research profile with the ability to publish and/or produce high quality research output. Papers or manuscripts deposited on a preprint server are acceptable. (a)(c) Essential Criteria 4 Sufficient breadth and depth of specialist knowledge in the research methods and techniques to relevant structural biology. (a)(c) Essential Criteria 5 Experience in at least one: 1.structural analysis, 2.biophysical methods relevant to protein complexes, 3.quantitative cell biology, 4.advanced electron microscopy. (a)(c)(d) Essential Criteria 6 Ability and potential to contribute to the development of funding proposals in order to generate external funding to support research projects. (a)(c) Essential Criteria 7 Ability to accurately and meticulously record procedures and results (both in notebooks and electronically). (a)(c) Essential Criteria 8 Competent in lab calculations. (b) Further Particulars Warwick Medical School For further information about the department, please visit the departmental website For further information about the University of Warwick, please read our University Further Particulars . Right to work in the UK If you do not yet have the right to work in the UK and/ or are seeking sponsorship under Tier 2 of the UK points-based immigration system please click on this link which contains further information about obtaining right to work in the UK and details about eligibility for sponsorship under Tier 2. Diversity and Inclusion The University of Warwick provides an inclusive working and learning environment, recognising and respecting every individual?s differences. We welcome applications from individuals who identify with any of the protected characteristics defined by the Equality Act 2010. Recruitment of Ex-Offenders Policy As an organisation using the (DBS) Disclosure and Barring Service to assess applicants? suitability for positions of trust, the University of Warwick complies with the DBS Code of Practice and undertakes not to discriminate unfairly against any subject of a Disclosure on the basis of a conviction or other information revealed. More information is available on the University?s Vacancy pages and applicants may request a copy of the DBS Code of Practice. Closing Date 6 May 2019 Apply Now Email this job to a friend
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